Reinforced Polymer–Nanoparticle Hydrogels for Subcutaneous and Sustained Delivery of Trastuzumab
Biologic therapy development is rapidly accelerating, requiring extended delivery formulation strategies. Supramolecular hydrogels and electrostatic complexation create subcutaneous depots that release clinically relevant trastuzumab doses in a controlled manner through simple component mixing without chemical modifications.
Giovanni Bovone+17 more
wiley +1 more source
Publisher Correction: Autonomous object tracking with vision based control using a 2DOF robotic arm. [PDF]
Sahu UK+6 more
europepmc +1 more source
Recent Applications of Mesoporous Silica Nanoparticles in Gene Therapy
The review summarizes the synthesis of mesoporous silica nanoparticles (MSNs) with modifiable surface properties, functionalization strategies, mechanism of therapeutic payload release, and current applications in gene therapy, focusing on their capabilities in the targeted delivery of therapeutic nucleic acids, CRISPR‐Cas systems, and other genetic ...
Tamanna Binte Huq+4 more
wiley +1 more source
Longitudinal changes and tracking of in-school physical activity in primary school children: four-year longitudinal study. [PDF]
Sasayama K, Yasunebe J, Adachi M.
europepmc +1 more source
This study developed 3D‐printable THA‐Col microgels for delivering BMP‐7 cmRNA. The key result is that hMSCs transfected on the biomaterials showed BMP‐7 secretion levels comparable to pre‐transfected hMSCs, therefore introducing a cmRNA‐activated matrix to promote bone healing.
Daphne van der Heide+7 more
wiley +1 more source
Analysis of Teachers' Visual Behaviour in Classes: A Systematic Review. [PDF]
Mendes R, Pereira M, Nobre P, Dias G.
europepmc +1 more source
Pyrophosphate‐Containing Calcium Phosphates Negatively Impact Heterotopic Bone Quality
The role of calcium pyrophosphate (Ca‐PP) in heterotopic bone formation and material degradation is investigated using calcium phosphate (CaP) compositions with varying Ca‐PP content. Results show that Ca‐PP does not impede heterotopic bone formation, minimally affects CaP degradation at non‐osseous sites, and increases phagocytosis.
Martina Jolic+7 more
wiley +1 more source
HEPSO-SMC: a sliding mode controller optimized by hybrid enhanced particle swarm algorithm for manipulators. [PDF]
Liu Z, Zhang T, Huang S, Wang H.
europepmc +1 more source
A wireless cortical surface implant employing graphene electrode arrays diagnoses and alleviates Parkinson's disease symptoms in freely moving animals. The device continuously monitors cortical activity and delivers targeted stimulation, restoring beta–gamma and delta oscillations.
Hongseong Shin+15 more
wiley +1 more source
Exploring cognitive effort and divergent thinking in metaphor translation using eye-tracking and EEG technology. [PDF]
Liu T, Wang Y, Wang Z, Yu H.
europepmc +1 more source