Results 41 to 50 of about 824,062 (379)

Detection rate for ESR1 mutations is higher in circulating‐tumor‐cell‐derived genomic DNA than in paired plasma cell‐free DNA samples as revealed by ddPCR

Molecular Oncology, EarlyView.
Analysis of ESR1 mutations in plasma cell‐free DNA (cfDNA) is highly important for the selection of treatment in patients with breast cancer. Using multiplex‐ddPCR and identical blood draws, we investigated whether circulating tumor cells (CTCs) and cfDNA provide similar or complementary information for ESR1 mutations.
Stavroula Smilkou, Aliki Ntzifa, Victoria Tserpeli, Ioanna Balgkouranidou, Alkistis Papatheodoridi, Evangelia Razis, Helena Linardou, Christos Papadimitriou, Amanda Psyrri, Flora Zagouri, Stylianos Kakolyris, Evi Lianidou   +11 more
wiley   +1 more source

A novel perspective on the regulation of cardiac cell beating: cardiac cell under mechanical stimulation acts as “cell activation button” to activate adjacent cardiac cell

Journal of Nanobiotechnology
The regulation of cardiac cell beating is of great significance for understanding cardiac coordination mechanisms and the treatment of cardiovascular diseases.
Zhaotong Chu, Yujie Zhang, Yidi Zhang, Hao Chen, Detian Zhang, Qingzheng Hao, Zuqi Wang, Mingzhu Sun, Xin Zhao, Yaowei Liu   +9 more
doaj   +1 more source

Tracing and characterization of foodborne botulism caused by the new MLST type Clostridium botulinum A2 in Hebei province, China

Frontiers in Microbiology
Foodborne botulism caused by botulinum neurotoxin (BoNT) remains an important form of botulism worldwide, with a high mortality rate and prolonged hospitalization time. Clostridium botulinum (C.
Ziwei Lu, Jinzhi Feng, Xia Luo, Hui Sun, Ying Huang, Shuangshuang Lu, Dai Wang, Xuefang Xu, Xuancheng Lu, Lixia Xu   +9 more
doaj   +1 more source

Cell‐free DNA aneuploidy score as a dynamic early response marker in prostate cancer

Molecular Oncology, EarlyView.
mFast‐SeqS‐based genome‐wide aneuploidy scores are concordant with aneuploidy scores obtained by whole genome sequencing from tumor tissue and can predict response to ARSI treatment at baseline and, at an early time point, to ARSI and taxanes. This assay can be easily performed at low cost and requires little input of cfDNA. Cell‐free circulating tumor
Khrystany T. Isebia, Anouk C. de Jong, Lisanne F. van Dessel, Vanja de Weerd, Corine Beaufort, Jean Helmijr, José Alberto Nakauma‐González, Job van Riet, Paul Hamberg, Daniel Vis, Michiel S. van der Heijden, Nick Beije, Martijn P. Lolkema, Teoman Deger, Saskia M. Wilting, Ronald de Wit, Maurice P. H. M. Jansen, John W. M. Martens   +17 more
wiley   +1 more source

On the efficiency of school tracking: a perspective from outcomes in dual VET in Switzerland

Journal for Labour Market Research, 2017
In this paper, we examine the efficiency of the sort done by the Swiss lower secondary school tracking system, looking at students’ outcomes in dual vocational education and training (VET)—the most common education type at the upper secondary level in ...
Joelle Latina, José V. Ramirez
doaj   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

The Structural Framework and Opening Appearance of the VP1-Pocket of Enteroviruses Correlated with Viral Thermostability

Pathogens
Enteroviruses (EVs and RVs) are prevalent worldwide and cause various diseases in humans, of which the VP1-pocket is a target of antivirals, with a lipid molecule as a pocket factor to stabilize the virion.
Xiaojing Lin, Jianhong Gan, Qiang Sun, Zi Li, Kun Qin, Yong Zhang, Yang Cao, Jianfang Zhou   +7 more
doaj   +1 more source

Use of eye tracking for assessment of electronic navigation competency in maritime training

Journal of Eye Movement Research, 2019
The purpose of this study is to experiment an assessment method using eye tracking technology in simulator based electronic navigation training of ship officers who play a critical role in maritime accidents. The maritime industry focuses on human factor
Oguz Atik, Omer Arslan
doaj   +1 more source

Big data in higher education: an action research on managing student engagement with business intelligence [PDF]

, 2013
This research aims to explore the value of Big Data in student engagement management. It presents an action research on applying BI in a UK higher education institution that has developed and implemented a student engagement tracking system (SES) for ...
Cao, Guangming, Duan, Yanqing, Ong, Vincent Koon, Woolley, Marcus   +3 more
core  

Big data for monitoring educational systems [PDF]

, 2017
This report considers “how advances in big data are likely to transform the context and methodology of monitoring educational systems within a long-term perspective (10-30 years) and impact the evidence based policy development in the sector”, big data ...
Berendt, Bettina, Blakemore, Michael, Kern, Philippe, Littlejohn, Allison, Mitros, Piotr, Shacklock, Xanthe   +5 more
core   +1 more source