Results 31 to 40 of about 876,743 (305)
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Arts Education in Michigan: Fostering Creativity and Innovation [PDF]
, 2012 In the fall of 2011, Quadrant Arts Education Research, in partnership with Michigan Youth Arts, the Michigan Council for Arts and Cultural Affairs, the Michigan Department of Education, and ArtServe Michigan, began a statewide study of arts education in ...
core
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
SensorsMechanical models are capable of simulating the deformation and stress distribution of oocytes under external forces, thereby providing insights into the underlying mechanisms of intracellular mechanical responses.
Yue Du +5 more
doaj +1 more source
The Myths and Justifications of Sex Segregation in Higher Education: VMI and The Citadel [PDF]
, 1997 Access to higher education, particularly to the specialized and elite education that is part of the tracking system leading to prestigious and highly remunerative positions, is a measure of equality.
Epstein, Cynthia Fuchs
core +2 more sources
NKCC1: A key regulator of glioblastoma progression
Molecular Oncology, EarlyView.Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen +5 more
wiley +1 more source
Eye tracking in physics education research: A systematic literature review
Physical Review Physics Education Research, 2022 Eye tracking is becoming increasingly popular in physics education research (PER). As technology has advanced considerably in recent years and has become more user friendly, it is anticipated that eye tracking will play an increasingly significant role ...
L. Hahn, P. Klein
doaj +1 more source
Role of Alumni Program in the Prediction of Career Success in an Ecuadorian Public University
Applied Sciences, 2022 Alumni tracking studies at the local, regional and global levels provide quality and efficiency measurement parameters in higher education institutions and project improvements in the quality of professionals.
Roberto Pico-Saltos +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source