Results 191 to 200 of about 135,228 (292)

Optimization and validation of traction performance for an eight-axle heavy-haul locomotive during gradient starting. [PDF]

Sci Rep
Liu Y, Wu X, Ma P, Yuan X.
europepmc   +1 more source

Humanized immune system animal models and their recent applications

Animal Models and Experimental Medicine, EarlyView.
In this review, we provide an updated and comprehensive overview of the current state of humanized immune system animal model research. We discuss the variety of techniques used to produce humanized mice with their respective strengths and weaknesses, and evaluate the advantages and limitations of these models, including issues with incomplete immune ...
Nicolas Skuli, Rudra B. Amin, A’ishah Bakayoko, Marisa Kruidenier, Sahara Aqui, Sarah J. Skuli, Terence P. Gade   +6 more
wiley   +1 more source

Bottom‐Up Coacervate‐Based Artificial Cells: Integrating Cellular Hallmarks into Complex Life‐Like Systems

Angewandte Chemie, EarlyView.
Current interest in artificial cell research underscores its potential to deepen our understanding of life's fundamental processes. This review highlights advances in bottom‐up coacervate‐based artificial cell engineering via combined integration of cellular hallmarks.
Arjan Hazegh Nikroo, Angshuman Das, Madelief A. M. Verwiel, Jan C. M. van Hest   +3 more
wiley   +2 more sources

The Interference Mechanism and Regularity Analysis of Gas Pipelines Affected by High-Speed Rail Based on Field Testing and Numerical Simulation. [PDF]

Materials (Basel)
Zhang Y, Ge C, Chang Z, Du Y, Lu M, Jiang Z.   +5 more
europepmc   +1 more source

Animal research in the UK: Regulation, implementation, welfare and development of new approach methodologies

Animal Models and Experimental Medicine, EarlyView.
Scientific research with animals in the UK is regulated by the Animals (Scientific Procedures) Act 1986 with the National Centre for the Replacement, Refinement and Reduction of Animals in Research providing support for best practice and facilitating development of new approach methodologies.
Ewan St. John Smith, James Bussell, Maggie Gentry, Elliot Lilley, Cathy Merry, Judy MacArthur Clark, William Reynolds   +6 more
wiley   +1 more source

Structural Design and Motion Characteristics Analysis of the Inner Wall Grinding Robot for PCCP Pipes. [PDF]

Sensors (Basel)
Cui Y, Sun R, Wu Z, Ge X, Cao Y.
europepmc   +1 more source

Nonviral Gold Nanoparticle‐Mediated Delivery of CRISPR‐Cas9 Ribonucleoprotein and Long DNA Transgenes Into Primary Blood Cells

Advanced NanoBiomed Research, EarlyView.
CRISPR/Cas9 has revolutionized the field of gene therapy, but delivery remains an outstanding issue. We propose a nonviral gold‐nanoparticle platform for co‐delivery of CRISPR/Cas9 ribonucleoprotein and long 2.1 kilobase dsDNA transgene constructs. This CRISPR‐AuNP is inexpensive to produce and mediate gene editing and DNA delivery in T cells and CD34+
Rachel A. Cunningham, Karthikeya S. V. Gottimukkala, Daniel D. Lane, Katrina Poljakov, Patricia Lipson, Mark R. Enstrom, Alessandro Rizzi, Aude G. Chapuis, Jennifer E. Adair   +8 more
wiley   +1 more source

Study on elasto-plastic zoning radius and failure characteristics of layered rock with a single hole under impact loading. [PDF]

Sci Rep
Liu Y, Miao Y, Huang Y.
europepmc   +1 more source

On the Molecular Diffusion Dynamics Between Subcutaneous Tissue and Microneedles for Wearable Continuous Glucose Monitoring

Advanced NanoBiomed Research, EarlyView.
In this study, we investigate the dynamics of glucose diffusion between subcutaneous tissue and hydrogel‐filled microneedles. Specifically, we examine how hydrogel thickness, microneedle size, and glucose concentration influence diffusion. This study provides an experimental reference to the wearable biosensor community researching microneedle‐based ...
Wensheng Lin, Binbin Cui, Xuecheng He, Suo Tu, Shilei Dai, Xinran Zhang, Ivo Pang, Xiaonan Chen, Jixiang Zhu, Shiming Zhang   +9 more
wiley   +1 more source

When energy is scarce, evolution selects dormancy. [PDF]

Proc Natl Acad Sci U S A
Kempes CP.
europepmc   +1 more source