Results 211 to 220 of about 1,062,732 (288)

Synthesis of a Stable Hydrophilic trans‐Cyclooctene Amino Acid Unlocks Fast Bioorthogonal Click Chemistry for the Generation of Antibody‐Drug Conjugates by Genetic Code Expansion

open access: yesAngewandte Chemie International Edition, EarlyView.
A novel trans‐cyclooctene (TCO) based noncanonical amino acid (ncAA) is reported, characterized by high hydrophilicity and remarkable stability to trans‐cis isomerization. Its incorporation via genetic code expansion into an antibody and subsequent conjugation resulted in a highly efficacious antibody‐drug conjugate (ADC).
Georgi R. Genov   +4 more
wiley   +1 more source

Physical Reservoir Computing Using Microelectromechanical Systems

open access: yesAdvanced Physics Research, EarlyView.
Physical reservoir computing (PRC) transforms micro‐electro‐mechanical (MEMS) sensors into intelligent computing nodes by utilizing their intrinsic nonlinear dynamics and short‐term memory effects. This review surveys recent progress in MEMS‐based reservoir computing, covering its theoretical foundations, device architectures, and applications in ...
Mariam Gada   +2 more
wiley   +1 more source

Morphological and morphometric aspects of the equine aortic valve: New insights for comparative studies in mammals

open access: yesThe Anatomical Record, EarlyView.
Abstract New data on the equine aortic valve obtained using advanced techniques is especially important given the greater availability of animal models for translational research. Here we characterized the morphological and morphometric aspects of the equine aortic valve from 60 healthy hearts collected at equine abattoirs.
Vitor Pires Pereira   +3 more
wiley   +1 more source

Integrating whole‐bone and regional analyses to understand human scapular growth

open access: yesThe Anatomical Record, EarlyView.
Abstract This study investigates ontogenetic changes in human scapular morphology using three‐dimensional geometric morphometrics with whole‐bone and region‐specific analyses. The aim is to evaluate whether the scapula follows a regular developmental pattern and whether its functionally distinct components, the scapular spine (SS) and glenoid fossa ...
Azahara Salazar‐Fernández   +3 more
wiley   +1 more source

Pelvic morphology and body size in relation to the preauricular sulcus: Evidence from medieval to modern Iberia

open access: yesThe Anatomical Record, EarlyView.
Abstract The preauricular sulcus has long been debated as a pelvic feature variably attributed to obstetric stress, ligamentous traction, and broader biomechanical processes. To clarify its determinants, we analyzed 409 adult individuals from three archeological and one early modern skeletal collection from the Iberian Peninsula, integrating graded ...
Rebeca García‐González   +5 more
wiley   +1 more source

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