Results 61 to 70 of about 37,321 (297)

Normal‐Appearing White Matter Injury Mediates Chronic Deep Venous Hypoxia and Disease Progression in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore how cerebral hypoxia and Normal‐Appearing White Matter (NAWM) integrity affect MS lesion burden and clinical course. Methods Seventy‐nine MS patients, including 13 clinically isolated syndrome (CIS) patients and 66 relapsing–remitting multiple sclerosis (RRMS) patients, and 44 healthy controls (HCs) were recruited from ...
Xinli Wang, Huiying Wang, Zhizheng Zhuo, Ai Guo, Ke Lv, Decai Tian, Chao Chai, Yunyun Duan, Shuang Xia   +8 more
wiley   +1 more source

Electric system design for 3 000 HP (full hybrid) shunting locomotive

机车电传动, 2022
The 3 000 HP full hybrid electric shunting locomotive was developed under a scientific research project approved by China State Railway Group Co., Ltd., to adapt to the increasing low-carbon, energy-saving and environmental protection requirements of the
WEN Jibin, ZHAO Gang, LIU Zhanyu, DU Fei, LYU Tingting, SUN Zhiwei   +5 more
doaj  

Integrating Dynamics and Wear Modelling to Predict Railway Wheel Profile Evolution [PDF]

, 2003
The aim of the work described was to predict wheel profile evolution by integrating multi-body dynamics simulations of a wheelset with a wear model. The wear modelling approach is based on a wear index commonly used in rail wear predictions.
A. Ward, F. Braghin, K. Bel Knani, P. Bologna, R Lewis, R. S. Dwyer-joyce, Rob Dwyer-joyce, S. Bruni, Stefano Bruni   +8 more
core   +1 more source

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

A Systematic Comparison of Alpha‐Synuclein Seed Amplification Assays for Increasing Reproducibility

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Seed amplification assays (SAAs) enable ultrasensitive detection of misfolded α‐synuclein across biofluids and tissues. Yet, heterogeneity in protocols limits cross‐study comparability and clinical translation. Here, we review α‐synuclein SAA methods and their performance across various biological matrices.
Manuela Amaral‐do‐Nascimento, Daniela F. Santos, Tuane C. R. G. Vieira, Tiago F. Outeiro   +3 more
wiley   +1 more source

Operating performance of an agricultural tractor fitted with two types of tyres under two types of terrain [PDF]

Revista Ciência Agronômica
The correct use of tyres on agricultural tractors, in respect of the terrain and the type and internal pressure of the tyre, are factors that influence the performance of the tractor. The aim of the present study was to evaluate the operating performance
Tainara Regina Cerutti Torres Bahia, Cristiano Marcio Alves de Souza, Jackson Antonio Barbosa, Roberto Carlos Orlando   +3 more
doaj   +1 more source

Study of high-speed angular-contact ball bearings under dynamic load [PDF]

, 1969
Research program studies behavior of specific high-speed, angular-contact ball bearings. Program is aimed at detailed investigation of ball-separator behavior and lubrication surface-finish effects in a specific gyro ...
Geer, T. E., Kannel, J. W., Stockwell, R. D., Walters, C. T., Wilson, W. R. D.   +4 more
core   +1 more source

Athermal rheology of weakly attractive soft particles

, 2016
We study the rheology of a soft particulate system where the inter-particle interactions are weakly attractive. Using extensive molecular dynamics simulations, we scan across a wide range of packing fractions ($\phi$), attraction strengths ($u$) and ...
Chaudhuri, Pinaki, Heussinger, Claus, Irani, Ehsan   +2 more
core   +1 more source

Discordance Between Patient and Physician Global Assessments in Early Systemic Sclerosis

Arthritis Care &Research, EarlyView.
Objective This study aims to identify factors associated with patient global assessment (PtGA) and physician global assessment (PhGA) and discordance between them in systemic sclerosis (SSc). Methods Data from adults with early SSc (<5 years) from the Collaborative National Quality and Efficacy Registry were included.
Ellen Romich, Alexis Ogdie, Alisa Stephens Shields, Peter A. Merkel, Shervin Assassi, Elana J. Bernstein, Andreea Bujor, Flavia V. Castelino, Lorinda Chung, Luke B. Evnin, Tracy M. Frech, Jessica K. Gordon, Melissa Griffith, Faye N. Hant, Monica L. Harding, Laura K. Hummers, Dinesh Khanna, Kimberly S. Lakin, Dorota J. Lebiedz‐Odrobina, Yiming Luo, Ashima Makol, Maureen D. Mayes, Zsuzsanna H. McMahan, Jerry Molitor, Duncan F. Moore, Julie Paik, Carrie Richardson, Brian Skaug, Ami A. Shah, Ankoor Shah, Virginia Steen, John M. VanBuren, Elizabeth R. Volkmann, Carleigh Zahn, Nora Sandorfi, for the CONQUER Investigators   +35 more
wiley   +1 more source

Modelling of 4WD vehicle driveability during tip-in/tip-out events [PDF]

, 2011
This paper describes a modelling method to investigate the dynamic behaviour of 4WD vehicle under a severe driving condition, where the driver applies a rapid tip-in on the accelerator pedal in 2nd gear to achieve maximum engine torque.
Bin Raja Ahsan Shah, Raja Mazuir, Cheng, Caizhen, Jones, R. Peter, Pawar, Jasjit   +3 more
core