Results 31 to 40 of about 178,302 (258)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Liberal trade policy and food insecurity across the income distribution: an observational analysis in 132 countries, 2014–17

The Lancet Global Health, 2020
Summary: Background: Eradicating food insecurity is necessary for achieving global health goals. Liberal trade policies might increase food supplies but how these policies influence individual-level food insecurity remains uncertain.
Pepita Barlow, DPhil, Rachel Loopstra, PhD, Valerie Tarasuk, ProfPhD, Aaron Reeves, PhD   +3 more
doaj   +1 more source

AUTONOMOUS AND REMOTELY CONTROLLED ROBOTIC SYSTEMS OF MEDICAL EVACUATION UNDER TRANSITION TO A DIGITAL ECONOMY: DEVELOPMENTS OF THE LOMONOSOV MOSCOW STATE UNIVERSITY AND THE ALL-RUSSIAN CENTER OF DISASTER MEDICINE “ZASCHITA” [PDF]

Население и экономика, 2018
Medical evacuation of severelly ill or injured patients is a complicated and expensive problem. Transportation is performed by highly-qualified medical crew and on special vehicles (automobiles, on-land and water transport).
Viktor A. Sadovnichy, L. Sokolova, N. Baranova, S. Goncharov, V. Staroverov, R. Solodova, M. Sokolov   +6 more
doaj   +3 more sources

Participation in International Integration Associations as a Factor of Ukraine’s Global Competitive Power

Studia Regionalne i Lokalne, 2023
Current glocalisation processes require the identification of priority areas for Ukraine’s further integration into the international economy. The right choice of direction, tools and forms of implementation allows the government to determine, justify ...
Olena Zayats, Olena Pryiatelchuk, Maryna Korol, Mykola Palinchak, Ihor Korol   +4 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Investigation of the potential anxiolytic effects of essential oils derived from two sacred plants of tantric buddhism: Rhododendron anthopogon d.don and Juniperus indica Bertol

BMC Complementary Medicine and Therapies
Background In the Southern Tibet region, the Nepalese and Indian Himalayas many plants rich in aromatic resins are burned by populations who follow Tantric Buddhism, for both daily sacred activities and religious ceremonies.
Laura Cornara, Marco Valussi, Khilendra Gurung, Lapka Sherpa Lama, Flavio Polito, Vincenzo De Feo   +5 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source