Results 31 to 40 of about 9,769,584 (248)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

TRADE UNION RECOGNITION IN MALAYSIA: LEGAL ISSUES

open access: yesUUM Journal of Legal Studies, 2020
In Malaysia, the Federal Constitution protects the worker’s enjoyment as to freedom of association, in particular, the right to form and join the trade union.
Siti Suraya Abd Razak
doaj   +5 more sources

Do we still need Fair Trade?

open access: yesJournal of Fair Trade, 2019
This is an opinion piece that looks at how the Fair Trade movement has evolved over time and questions why the movement has lost momentum. This article investigates whether the world still needs Fair Trade and, if so, what the future of the Fair Trade ...
Mira Mookerjee
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

AUTONOMOUS AND REMOTELY CONTROLLED ROBOTIC SYSTEMS OF MEDICAL EVACUATION UNDER TRANSITION TO A DIGITAL ECONOMY: DEVELOPMENTS OF THE LOMONOSOV MOSCOW STATE UNIVERSITY AND THE ALL-RUSSIAN CENTER OF DISASTER MEDICINE “ZASCHITA” [PDF]

open access: yesНаселение и экономика, 2018
Medical evacuation of severelly ill or injured patients is a complicated and expensive problem. Transportation is performed by highly-qualified medical crew and on special vehicles (automobiles, on-land and water transport).
Viktor A. Sadovnichy   +6 more
doaj   +3 more sources

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

Liberal trade policy and food insecurity across the income distribution: an observational analysis in 132 countries, 2014–17

open access: yesThe Lancet Global Health, 2020
Summary: Background: Eradicating food insecurity is necessary for achieving global health goals. Liberal trade policies might increase food supplies but how these policies influence individual-level food insecurity remains uncertain.
Pepita Barlow, DPhil   +3 more
doaj   +1 more source

Participation in International Integration Associations as a Factor of Ukraine’s Global Competitive Power

open access: yesStudia Regionalne i Lokalne, 2023
Current glocalisation processes require the identification of priority areas for Ukraine’s further integration into the international economy. The right choice of direction, tools and forms of implementation allows the government to determine, justify ...
Olena Zayats   +4 more
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

open access: yesMolecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

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