Results 41 to 50 of about 9,769,584 (248)

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Victorian Tailoresses' Association records [PDF]

, 1882
This collection contains the membership register and Strike Attendance Book, 1883-1884 of the Tailoresses' Association of Melbourne. The Pressers' Union, which had formed in 1884, amalgamated with the Cutters' & Joiners' Union in 1902 to form the ...
Victorian Tailoresses' Association
core  

Digital and sustainable trade facilitation in the Association of Southeast Asian Nations (ASEAN) 2023

, 2023
Based on the United Nations Global Survey on Digital and Sustainable Trade FacilitationThis report was Jointly prepared by ESCAP and the ASEAN Secretariat.
UN.ESCAP, Association of Southeast Asian Nations (ASEAN)   +1 more
core   +1 more source

Investigation of the potential anxiolytic effects of essential oils derived from two sacred plants of tantric buddhism: Rhododendron anthopogon d.don and Juniperus indica Bertol

BMC Complementary Medicine and Therapies
Background In the Southern Tibet region, the Nepalese and Indian Himalayas many plants rich in aromatic resins are burned by populations who follow Tantric Buddhism, for both daily sacred activities and religious ceremonies.
Laura Cornara, Marco Valussi, Khilendra Gurung, Lapka Sherpa Lama, Flavio Polito, Vincenzo De Feo   +5 more
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Are trade and transport logistics activities mutually reinforcing? Some empirical evidences from ASEAN countries

Journal of Shipping and Trade, 2019
Both trade and transport logistics activities have impressively flourished among the Association of Southeast Asian Nations (ASEAN) countries over the past decades.
Kee-hung Lai, Yu Pang, Christina W. Y. Wong, Y. H. Venus Lun, Y. N. Eppie Ng   +4 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Collective trade marks: a comparative legal study of the legislation of the European Union and Ukraine

Теорія і практика інтелектуальної власності
The article examines the legal regulation of collective trade marks under the legislation of the European Union and Ukraine. The subject matter of the study encompasses the concept, functions, eligible entities, registration procedure, and specific ...
Natalya Lemeshchuk, Oleksandr Besedkov
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source