Results 41 to 50 of about 178,302 (258)
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Journal of Shipping and Trade, 2019 Both trade and transport logistics activities have impressively flourished among the Association of Southeast Asian Nations (ASEAN) countries over the past decades.
Kee-hung Lai +4 more
doaj +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
FEBS Open Bio, EarlyView.Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young +7 more
wiley +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
Optimizing photoexcitation conditions for time‐resolved X‐ray solution scattering experiments
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering (TR‐XSS) is a powerful technique to visualize how proteins change their structure in real time after light activation. Selecting the right laser photoexcitation conditions—fluence, excitation geometry, and sample refresh rate—is critical to maximize the experimental signal while avoiding unwanted side effects ...
Matteo Levantino
wiley +1 more source
Integration Processes in Latin America
Latin American Journal of Trade Policy, 2018 After describing, within the framework of “Open Regionalism”, the tortuous process that the Central American countries have experienced to achieve their integration as a Common Market, this article analyses the relationship between these countries and ...
Joaquín Flores Paredes +2 more
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Are Trade Associations Dead? [PDF]
Journal of Toxicology: Cutaneous and Ocular Toxicology, 1994 (1994). Are Trade Associations Dead? Journal of Toxicology: Cutaneous and Ocular Toxicology: Vol. 13, No. 1, pp. 1-2.
openaire +1 more source
Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source
Opportunities for Doing Business with Countries Neighbouring V4 - The Case of Ukraine
Entrepreneurial Business and Economics Review, 2013 Objective: The main objective is to present the business environment of Ukraine in terms of the possible association with the EU or joining the Customs Union, with expectations for V4 countries, regarding trade relations, potential business ...
Jana Gálová
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