Results 41 to 50 of about 3,389,688 (248)

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

The US-China trade war: interrogating globalisation of technology

open access: yesCogent Social Sciences
The US-China trade War in 2018 is one of the 595 documented trade-related disputes reported by the WTO since 1995. Despite the January 2020 agreement between the two countries, the causes of the trade wars appear implicated in international economic ...
Nzube A. Chukwuma   +2 more
doaj   +1 more source

The impact of the US-China trade war on Vietnamese exports to the US: a quantitative study using DiD approach [PDF]

open access: yesJournal of Trade Science
Purpose – The study attempts to examine the impact of the US-China trade war on Vietnamese exports to the United States, which has consistently served as a key market for Vietnamese goods and services in recent decades.
Binh Thi Thanh Dang   +2 more
doaj   +1 more source

Spatial biology in cancer epigenetics

open access: yesMolecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

open access: yesMolecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh   +11 more
wiley   +1 more source

Political Economy of Anglo-French Trade, 1689-1899:Agricultural Trade Policies, Alcohol Taxes and War [PDF]

open access: yes
Britain – contrary to received wisdom – was not a free trader for most of the 1800s and, despite repeal of the Corn Laws, continued to have higher tariffs than the French until the last quarter of the century War with Louis XIV from 1689 led to the end ...
Nye, John V.C.
core   +2 more sources

US-China trade war on ASEAN region: oligopoly or systemic market structure?

open access: yesCogent Business & Management
The trade war between the United States and China since 2008 has opened strategic opportunities to increase the economic market in ASEAN countries. This research aims to answer whether the trade war led to an oligopoly or a systemic market structure as a
Ignatia Martha Hendrati   +4 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

open access: yesFEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova   +2 more
wiley   +1 more source

The Current World-System and Conflicts

open access: yesJournal of World-Systems Research
Under the Trump presidency, the United States and China were embroiled in an open trade war that threatened the neoliberal world order. This paper attempts to put forward an explanation of the trade war from a world-systems perspective.
Ishmael Hlovor, Lord Mawuko-Yevugah
doaj   +1 more source

U.S.-China trade war and its impact on the world economy

open access: yesОлон улс судлал, 2020
Republican candidate Donald J. Trump, who ran in the 2016 US presidential elections with a slogan “Make America Great Again” defined his foreign policy as “America First”.
Byambakhand Luguusharav, Bolormaa Budjav
doaj   +1 more source

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