Results 41 to 50 of about 4,990,585 (292)
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Experiments with Body Agent Architecture [PDF]
, 2022 Experiments with Body Agent Architecture puts forward the notion of body agents: non-ideal, animate and highly specific figures integrated with design to enact particular notions of embodied subjectivity in architecture. Body agents present opportunities
Ayuso, Alessandro
core +1 more source
Reconnecting With the Past: Traditional Tongan Architecture as an Educational Device for the Tongan People [PDF]
, 2016 The complexity of the traditional Tongan fale has decreased over time, but there is a need for architects to revive the essence and the cultural aspects of the fale.
Nonu, Paula
core +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
, 2020 Traditional architecture displaces all possible thoughts about the need for more complicated houses and buildings. Strongly taking the position of natural architecture - it has become the foundation of all sorts of styles and cultures in architecture. The article talks about the origin and development of traditional architecture.
El Alaoui S. +3 more
openaire +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
KOSMOLOGI DALAM ARSITEKTUR TORAJA
Dimensi: Journal of Architecture and Built Environment, 2001 Modernism in architecture always has a concrete, profane and clear concept.On the totally contrary, traditional architecture traditional has an abstract, spiritual and often religious concept or way of thinking.
Yulianto Sumalyo
doaj
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source