Results 181 to 190 of about 54,235 (259)

Qingdainone, a novel bioactive compound in Realgar‒Indigo naturalis, induced apoptosis and differentiation in ATRA‐sensitive and ‐resistant acute promyelocytic leukaemia cells

Clinical and Translational Discovery, Volume 6, Issue 3, June 2026.
1. Network pharmacology identified Qingdainone as a key bioactive compound in RIF. 2. Molecular docking revealed strong binding affinities of Qingdainone to targets such as CCND1, CDK1, CDK4, CASP3 and CASP7. 3. Qingdainone interfered proliferation and apoptosis, and promoted differentiation, of ATRA‐sensitive and ‐resistant APL cells, such that ...
Pengcheng Xu, Yang Ou, Xin Tan, Lili Ji, Yanxia Zhan, Pu Chen, Hao Chen, Yunfeng Cheng   +7 more
wiley   +1 more source

Mechanisms of Gui Zhi Fu Ling Formula in Liver Fibrosis: Metabolomics and Gut Microbiota Analysis

eFood, Volume 7, Issue 3, June 2026.
Our study was based on the efficacy of the phenotype in an animal model and used multi‐omics to explore the mechanism of action of the compound. We found that Gui Zhi Fu Ling Formula may ameliorate hepatic fibrosis potentially associated with increased hepatic EPA and the expression of gut Pseudomonas.
Xiaoliang Deng, Yanqun Luo, Ying Gao, Yi Su, Haiping Xue, Tao Wu   +5 more
wiley   +1 more source

Author Correction: MiRNA-target network analysis identifies potential biomarkers for Traditional Chinese Medicine (TCM) syndrome development evaluation in hepatitis B caused liver cirrhosis. [PDF]

Sci Rep, 2020
Liu Y, Wang M, Luo Y, Chen J, Lu Y, Shi Y, Tang C, Zhou Q, Zhang H, Hu Y, Su S, Chen Q.   +11 more
europepmc   +1 more source

The Supporting Role of Natural Products as Effective Adjuvants in Cancer Immunotherapy

eFood, Volume 7, Issue 3, June 2026.
Natural products, as multi‐target and low‐toxicity adjuvants, enhance immune checkpoint inhibitor responses and reduce immune‐related adverse events through T cell reprogramming, microenvironment remodeling, and microbiota‐immune modulation. ABSTRACT Immune checkpoint inhibitors (ICIs) have revolutionized the treatment landscape of malignant tumors ...
Boyang Liu, Yubin Huang, Jianjun Deng, Zhijun Mao, Xue Bai, Longyang Ma, Jianhua Wang   +6 more
wiley   +1 more source

Advances in Research on the Protective Mechanisms of Traditional Chinese Medicine (TCM) in Islet β Cells. [PDF]

Evid Based Complement Alternat Med, 2019
Li N, Zhang H, Li X.
europepmc   +1 more source

Polygonati Rhizoma Attenuates Oxidative Stress‐Induced Senescence in Periodontal Ligament Stem Cells

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
Network pharmacology identified the potential targets and pathways of Polygonati Rhizoma (PR) against aging‐related periodontitis through PPI, GO/KEGG enrichment, and molecular docking. Experimental validation in a D‐galactose‐induced senescence model of periodontal ligament stem cells showed that PR‐medicated serum attenuated cellular senescence and ...
Xinran Feng, Ying An, Fanfan Hou, Qian Guo, Shanshan Cai, Hongbin Xu, Youfu He   +6 more
wiley   +1 more source

Polyphenol‐Rich Duhuo Jisheng Decoction Enhances Mesenchymal Stem Cell–Derived Exosome–Mediated Chondroprotection via PI3K/AKT Signaling in Osteoarthritis

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
This graphical abstract illustrates the chondroprotective mechanism of exosomes derived from bone marrow mesenchymal stem cells (BMSCs) preconditioned with polyphenol‐rich Duhuo Jisheng Decoction (DHJST‐Exos). Enriched with bioactive compounds such as wogonin, quercetin, and kaempferol, DHJST‐Exos effectively ameliorate osteoarthritis (OA ...
Zhouwei Liao, Weiran Wang, Shunwan Jiang, Lixin Wang, Tian Yu, Xinqiang Ni, Shaoqun Zhang, Jun Liu, Junzheng Yang, Hui Xie   +9 more
wiley   +1 more source

Antihyperuricemic Effect of Hawthorn Flavonoid Vitexin: LC–MS Analysis, Network Pharmacology, and In Vivo Verification of Molecular Mechanisms

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
UPLC‐MS/MS analysis of hawthorn flavonoids combined with network pharmacology, molecular docking, and molecular dynamics studies predicted vitexin as a key compound acting on the PPARγ/ABCG2 pathway. In a hyperuricemic mouse model, vitexin effectively lowered serum uric acid by enhancing renal and intestinal urate excretion, inhibiting urate production,
Shu‐Yu Wu, Kai‐Wen Kang, Dan‐Yu Huang, Shu‐Ying Li, Hao Zheng, Ri‐Hui Wu, Hui‐Qing Lv, Wan‐Bin Song, Jing Chen, Cheng‐Ping Wen, Li‐She Gan, Xiao Yuan   +11 more
wiley   +1 more source

Exploring the Mechanisms of Total Saponins of Black Ginseng and Ginsenoside Rg3 Against Doxorubicin‐Induced Cardiotoxicity

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
TSF and Rg3 demonstrate significant cardioprotective effects against DOX‐induced cardiotoxicity (DIC) by mitigating oxidative stress, inflammation, and apoptosis while preserving mitochondrial function. These findings provide novel insights into the clinical relevance of TSF and Rg3 in the management of DIC.
Linlin Liu, Peiyuan Dou, Xiaotong Zhang, Xiaoku Ran, Deqiang Dou, Xiaodong Lv   +5 more
wiley   +1 more source

Enteromorpha prolifera Polysaccharide Alleviates Type 2 Diabetes via the Gut Microbiota–Liver Axis to Modulate Cholesterol Metabolism

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
Enteromorpha prolifera polysaccharides may help restore lipid metabolism homeostasis by gently remodeling the gut microbiota to enrich beneficial bacteria and SCFAs, which in turn appears to modulate hepatic functions through the portal vein by downregulating cholesterol synthesis and promoting its metabolism. This coordinated process potentially leads
Liuying Zhu, Xusheng Wen, Wenrong Zhu, Xueqian Hu, Yanqun Xu, Xin Peng   +5 more
wiley   +1 more source