Results 51 to 60 of about 75,375 (316)
Advanced Science, EarlyView.CSPG4 is identified as a high‐value, stemness‐associated target in HPV‐negative HNSCC. By implementing rational biophysical engineering, a humanized and charge‐optimized CAR is developed to overcome tonic signaling‐induced exhaustion. This strategy induces a profound transcriptomic shift toward a rejuvenated, stem‐like memory state, significantly ...
Xiang Xu +13 more
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Pharmacological Research - Modern Chinese MedicineIntroduction: The compatibility of Traditional Chinese Medicine (TCM) holds the potential for reducing toxicity and enhancing efficacy, serving as a crucial guide for the clinical application of TCM.
Qiwu Jiang, Suhan Yang, Shan He, Fei Li
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The Neuroanatomic Basis of the Acupuncture Principal Meridians [PDF]
, 2009 Acupuncture involves treating illness by inserting needles at specified body locations (acupoints). The Principal meridians are pathways that join acupoints with related physiologic effects.
Peter Dorsher
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T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities
Advanced Science, EarlyView.T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu +7 more
wiley +1 more source
When the East Meets the West: the Future of Traditional Chinese Medicine in the 21st Century
康复学报, 2016 Traditional Chinese medicine (TCM) has a history of thousands of years, is a very valuable treasure left by our ancestors, and there are many things which are worth our in-depth mining. But in the past hundreds of years, with the Western medicine came to
Jin QIU
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康复学报, 2021 Ischemic stroke (cerebral infarction) is a common clinical disease of ischemic necrosis or softening of localized brain tissue, which belongs to "stroke disease" in traditional Chinese medicine (TCM).
Working Group of Clinical Practice Guidelines of Chinese Medicine Rehabilitation for Ischemic Stroke (Cerebral Infarction)
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Frontiers in Cellular and Infection Microbiology, 2022 The rising incidence of ulcerative colitis has become a new challenge for public health. Chimonanthus nitens Oliv. leaf granule (COG) is a natural medicine used for the treatment of respiratory diseases, which has excellent anti-inflammatory and ...
Jia-Qi Huang +11 more
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Generation of CCR4/CD7 Bispecific CAR‐T Cells Resistant to Fratricide and Exhaustion
Advanced Science, EarlyView.The applications of CAR T‐cell therapy in T‐cell malignancies face limitations such as fratricide, effector‐cell exhaustion, and antigen‐escape. Herein, we developed fratricide‐ and exhaustion‐resistant CAR‐T cells that targeted CCR4 and CD7 simultaneously, with optional EGFRt safety switch. Additionally, scRNA‐seq unveiled new molecular targets, which
Sile Li +10 more
wiley +1 more source
Sports and Chinese herbal medicine
Pharmacological Research - Modern Chinese Medicine, 2023 Background: Chinese herbs have been used in sports and exercises as potent remedies for the treatment of sports injuries and recovery from sports fatigue. Herbs such as Astragalus, Radix Codonopsis, Shiitake and Rhodiola are favoured for their ability to
ZeHua Yu +5 more
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The Structural Strategies of the International Branding in Traditional Chinese Medicine (TCM) in the Era of Technology Upgrading [PDF]
, 2022 Leman Wu
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