Results 51 to 60 of about 7,584,615 (297)

Uhrf1‐Mediated PKM2 Degradation via Ubiquitination Alleviates Inflammation and Pyroptosis in Inflammatory Bowel Disease

Advanced Science, EarlyView.
Uhrf1‐mediated PKM2 ubiquitination and degradation repressed the nuclear translocation of PKM2, and EPT served as a molecular glue capable of targeting the Uhrf1–PKM2 complex to alleviate the IBD course, suggesting that the Uhrf1–PKM2 axis was a previously unrecognized strategy for treating IBD.
Juan Zhang, Xin‐Rong Xu, Hui‐Lin Zhang, Qi‐Meng Zhu, Xin‐Yuan Li, Xi‐Peng Shang, Jing‐Hui Du, Christophe Morisseau, Feng Qiu, Cheng‐Peng Sun   +9 more
wiley   +1 more source

Standardization Guidelines for Chinese Medicine Rehabilitation

, 2019
To further facilitate the public health project"Standardization of Capacity Construction of TCM Rehabilitation Service", Chinese Medicine of Technology and Development Center for TCM of China and Research Base of Standards of Chinese Medicine ...
Weichi GUO, Xiaoyan LAN, Yangyang WANG, Research Base of Standards for Chinese Medicine Rehabilitation of National Administration of Traditional Chinese Medicine, Runsheng XIE, Technology and Development Center for TCM of China, Hui LI   +6 more
core   +1 more source

A BSCB‐Penetrating Nanoplatform for Enhanced Luteolin Delivery in PRMT2‐Targeted Epigenetic Therapy of Spinal Cord Injury

Advanced Science, EarlyView.
In this work, MSN‐BO@LUT penetrates the blood‐spinal cord barrier for luteolin delivery in spinal cord injury. The nanodrug suppresses neuroinflammation and promotes functional recovery of the spinal cord. Mechanistically, luteolin targets protein arginine N‐methyltransferase (PRMT2) to decrease toll‐like receptor 4 (TLR4) methylation, thereby ...
Yixuan Wang, Bo Jin, Shipian Li, Qianxi Ouyang, Yu Xiao, Jiaxin Wen, Yehua Lai, Ping Wang, Yongjun Wang, Xuejun Cui, Weian Zhang, Min Yao   +11 more
wiley   +1 more source

When the East Meets the West: the Future of Traditional Chinese Medicine in the 21st Century

康复学报, 2016
Traditional Chinese medicine (TCM) has a history of thousands of years, is a very valuable treasure left by our ancestors, and there are many things which are worth our in-depth mining. But in the past hundreds of years, with the Western medicine came to
Jin QIU
doaj  

AI drug discovery tools and analysis technology: New methods aid in studying the compatibility of Traditional Chinese Medicine

Pharmacological Research - Modern Chinese Medicine
Introduction: The compatibility of Traditional Chinese Medicine (TCM) holds the potential for reducing toxicity and enhancing efficacy, serving as a crucial guide for the clinical application of TCM.
Qiwu Jiang, Suhan Yang, Shan He, Fei Li
doaj   +1 more source

SChLAP1 contributes to non-small cell lung cancer cell progression and immune evasion through regulating the AUF1/PD-L1 axis

Autoimmunity, 2021
SChLAP1 is recently reported as a key oncogenic long non-coding RNA in human cancer. However, whether SChLAP1 functions in non-small cell lung cancer (NSCLC) and its specific potential regulatory mechanism remain unexplored.
Zhonghai Du, Shuxian Niu, Juan Wang, Jun Wu, Sheng Li, Xiuxiu Yi   +5 more
doaj   +1 more source

Developing TCM clinical practice guidelines: A comparison between traditional Chinese medicine and western medicine

, 2023
Clinical practice guidelines in Traditional Chinese Medicine (CPG-TCM) is the recommendation that aims to provide the best service to users by identifying and summarizing the rules of prevention, diagnosis, treatment, rehabilitation, and regression of ...
Xuping Song, Xuan Yu, Meng Luo, Shouyuan Wu, Yue Hu, Hongmei Zhao, Yaolong Chen, Xiaohui Wang, Juanjuan Zhang   +8 more
core   +1 more source

A Huaxian Formula Nanoformulation Confers Protection Against Acute Radiation‐Induced Lung Injury by Targeting Ferroptosis

Advanced Science, EarlyView.
An inhalable, nanoengineered herbal therapy achieves protection against acute radiation‐induced lung injury via self‐assembled nanomicelle‐mediated pulmonary targeting and a previously unrecognized dual mechanism that attenuates oxidative stress while inhibiting ferroptosis in alveolar epithelial cells.
Li Quan, Junyang Chen, Xingmin Chen, Zengyi Fang, Yuanzhen Mi, Pingjin Zou, Shunlian Fu, Huakang Li, Ke Xu, Bing Lin, Jinyi Lang, Meihua Chen   +11 more
wiley   +1 more source

NSUN2‐Mediated m5C Modification of TGFB1 in Trophoblasts Remodels Macrophage Function to Prevent URSA

Advanced Science, EarlyView.
NSUN2 and m5C decline in URSA villous tissues. Trophoblast Nsun2 ablation disrupts macrophage‐mediated maternal‐fetal tolerance and triggers embryo resorption. Mechanistically, NSUN2‐YBX1 axis stabilizes m5C‐modified TGFB1 mRNA to maintain TGF‐β1 secretion and M2 polarization, and restoring this signaling rescues maternal‐fetal immune tolerance to ...
Xiaoxiao Zhu, Xinkui Liu, Xiaoyan Yu, Qiaoqiao Han, Feifei Shi, Weiwei Song, Lu Liu, Chu Chu, Chenyang Shen, Zhen Zhang, Xia Li   +10 more
wiley   +1 more source

An investigation Into Traditional Chinese Medicine Hospitals in China: Development Trend and Medical Service Innovation [PDF]

International Journal of Health Policy and Management, 2017
Background This paper aims to investigate the development trend of traditional Chinese medicine (TCM) hospitals in China and explore their medical service innovations, with special reference to the changing co-existence with western medicine (WM) at ...
Liang Wang, Sizhuo Suo, Jian Li, Yuanjia Hu, Peng Li, Yitao Wang, Hao Hu   +6 more
doaj   +1 more source