Results 101 to 110 of about 1,136,484 (306)
FEBS Open Bio, EarlyView.The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen +8 more
wiley +1 more source
EmerT – a web based decision support tool for Traffic Management [PDF]
, 2012 This paper describes the EmerT portal (Emergency mobility of rescue forces and regular Traffic), an extended version of the DELPHI web tool. EmerT is a web decision support application for real time traffic situation, prognosis and traffic simulation ...
Bieker, Laura +2 more
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, 2012 Traffic demand and supply are in mutual interaction andmutually coordinated.Transport needs (of goods and passengers) cause an increasein consumption, and on the other hand influence theconstruction and improvement of available traffic capacities,which ...
Teodor Perić
core +1 more source
FEBS Open Bio, EarlyView.TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao +10 more
wiley +1 more source
RAQ–A Random Forest Approach for Predicting Air Quality in Urban Sensing Systems
Sensors, 2016 Air quality information such as the concentration of PM2.5 is of great significance for human health and city management. It affects the way of traveling, urban planning, government policies and so on.
Ruiyun Yu +4 more
doaj +1 more source
Self-Organizing Traffic at a Malfunctioning Intersection [PDF]
Traffic signals and traffic flow models have been studied extensively in the past and have provided valuable insights on the design of signalling systems, congestion control, and punitive policies. This paper takes a slightly different tack and describes
Sugata Mitra, Sujai Kumar
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FEBS Open Bio, EarlyView.This minireview explores fluorination as a key strategy to optimize therapeutic molecules and nanocarriers. By incorporating different fluorinated motifs—from single atoms to linear and branched chains—drug delivery, cellular uptake, and colloidal stability can be improved and fine‐tuned.
Martina Beccalli +2 more
wiley +1 more source
IET Intelligent Transport SystemsThe ability to understand the underlying fundamentals of traffic flow behaviour facilitates improved planning and decision‐making for road operators.
Erik Giesen Loo +3 more
doaj +1 more source
, 2014 Ceased with Mar 2020."Traffic Fatalities: Traffic fatalities per 100 million vehicle miles traveled."This archived document is maintained by the State Library of Oregon as part of the Oregon Documents Depository Program.
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Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source