Results 191 to 200 of about 3,312,575 (362)
Advanced Science, EarlyView.CTSK plays a critical role in pulmonary fibrosis. Excessive CTSK accumulation interacts with SNX9 to enhance TGF‐β1‐induced SMAD3 activation and GLS1 expression in fibroblasts, driving glutamine metabolism for collagen biosynthesis and exacerbating pulmonary fibrosis.
Mengting Chen +10 more
wiley +1 more source
Dynein‐Dependent Endo‐Lysosomal Degradation Drives Lewy Body Disorders Accompanied by Aβ Pathology
Advanced Science, EarlyView.This study investigates the impact of Aβ plaques on α‐synuclein (αSyn) pathologies in dementia with Lewy bodies (DLB). Co‐culturing primary neurons with AD mouse brain slices reveals impaired dynein‐dependent organelle trafficking, affecting αSyn degradation. Activating Rab7 restores this process, reducing αSyn inclusions.
Linlin Zhou +14 more
wiley +1 more source
Research on traffic state prediction method based on traffic flow prediction under multi-time granularity. [PDF]
Sci RepChen Y, Lu J.
europepmc +1 more source
Designing Tunable DNA Condensates to Control Membrane Budding Transformation in Synthetic Cells
Advanced Science, EarlyView.In giant unilamellar vesicles (GUVs), membrane wetting of encapsulated liquid‐liquid phase‐separated DNA condensates can be precisely triggered post‐fabrication using photoactivatable DNA‐lipid linkers. On free‐standing membranes, interactions between DNA condensates and the membrane lead to outward budding, resembling exocytosis.
Nastasja Kaletta +3 more
wiley +1 more source
Short-term traffic flow prediction research based on ICEEMDAN-MPE-PSO-DELM model. [PDF]
Sci RepTian X, Ding J, Liu H, Xing X, Liu J.
europepmc +1 more source
Post‐Translational Modifications in Cilia and Ciliopathies
Advanced Science, EarlyView.This review synthesizes current understanding of post‐translational modifications (PTMs) in ciliary proteins and emphasizes their roles in ciliary formation, homeostasis, and signaling. This review also discusses the implication of PTM dysregulation in ciliopathies and explores therapeutic strategies targeting PTM‐modifying enzymes.
Jie Ran, Jun Zhou
wiley +1 more source
A comprehensive accident investigation system for assisted driving vehicles: Addressing complexities in fault determination and responsibility allocation. [PDF]
PLoS OneHu Y, Zhou W.
europepmc +1 more source