Results 211 to 220 of about 613,794 (269)

Secreted Nonstructural Protein 3 is a Pathogenic Determinant of Orbivirus

Advanced Science, EarlyView.
This study uncovers a conserved PIP2‐dependent secretory pathway of orbivirus NS3 that induces vascular leakage. Pharmacological disruption of PIP2‐NS3 interaction significantly reduces viral pathogenicity and provides protective efficacy in murine models, establishing PIP2‐mediated NS3 secretion as both a key virulence determinant and a promising ...
Junyong Guan, Dong Zhou, Ran Shao, Xing Liu, Jin Peng, Yingran Huang, Shuhui Qi, Cankun Xi, Menghang Wang, Bin Sun, Yinglin Qi, Xin Yin   +11 more
wiley   +1 more source

Mechanically Triggered DNA Nanovehicles for Targeted Dual‐Drug Cancer Therapy

Advanced Science, EarlyView.
A mechanically triggered DNA nanovehicle is introduced that co‐releases two anticancer drugs in response to integrin‐mediated cellular forces. Cholesterol‐anchored DNA assemblies undergo force‐induced unfolding at cell–cell junctions, enabling selective, localized dual‐drug activation in cancer cells while minimizing off‐target toxicity in low‐tension ...
Murali Mohana Rao Singuru, Priyanka Bhattacharyya, Mingxu You   +2 more
wiley   +1 more source

ANXA2‐mediated Phagocytosis Generates AR+ Macrophages to Confer Enzalutamide Resistance in Prostate Cancer

Advanced Science, EarlyView.
A novel resistance mechanism is mediated through phagocytosis of cancer cells by AR+ TAMs. This process, dependent on ANXA2, enables macrophages to acquire AR protein from engulfed tumor cells. The internalized AR translocates into the macrophage nucleus, where it binds directly to the IL‐6 promoter, augmenting IL‐6 transcription and secretion ...
Yong Luo, Tianlong Luo, Lingfeng Li, Qi Sun, Dongquan Li, Shanhe Huang, Zonglin Li, Weilong Lin, Yuan Ou, Tao Du, Shengmeng Peng, Kewei Xu, Bisheng Cheng, Hai Huang   +13 more
wiley   +1 more source

Faster and Durable: A Cell‐to‐System Validation of a Low‐Degradation Fast‐Charge Protocol for Li‐Ion Batteries

Advanced Science, EarlyView.
A physics‐based framework resolving graphite phase‐separation dynamics establishes a predictive, degradation‐aware fast‐charging methodology for commercial Li‐ion batteries. The resulting model‐informed protocol achieves 20%–80% state‐of‐charge in 14 min while matching the long‐term degradation of a commercial 25‐minute EV strategy.
Marco Lagnoni, Francesco Giuseppe Quilici, Davide Cademartori, Claudio Scarpelli, Uways Nurulain Mithoowani, Federica Barontini, Alessandro Ruvio, Monica Puccini, Giovanni Lutzemberger, Maria Paola Carpanese, Antonio Bertei   +10 more
wiley   +1 more source

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Traffic Control Through Traffic Density

2019 3rd European Conference on Electrical Engineering and Computer Science (EECS), 2019
The article is focused on dynamic driving in road transport. Current systems on the market are referred to as dynamic but have their limitations. Traffic management is an important aspect to ensure the proper functioning and safety of transport as an element of critical infrastructure.
Jan Mrázek, Lucia Duricova Mrazkova, Martin Hromada   +2 more
openaire   +2 more sources

Traffic Equilibrium with Responsive Traffic Control

Transportation Science, 1993
This paper presents a theory of traffic equilibrium which involves responsive signal control policies; in this theory drivers' route choices and the control policy's choice of green times are treated in a symmetrical manner. The central theme of the paper is the iterative optimization assignment algorithm.
M. J. Smith, T. van Vuren
openaire   +1 more source

Traffic prediction for dynamic traffic engineering considering traffic variation

2013 IEEE Global Communications Conference (GLOBECOM), 2013
Traffic engineering with traffic prediction is one approach to accommodate time-varying traffic without frequent route changes. In this approach, the routes are calculated so as to avoid congestion based on the predicted traffic. The accuracy of the traffic prediction however has large impacts on this approach.
Tatsuya Otoshi, Yuichi Ohsita, Masayuki Murata 0001, Yousuke Takahashi, Keisuke Ishibashi, Kohei Shiomoto   +5 more
openaire   +1 more source

Traffic prediction for dynamic traffic engineering

Computer Networks, 2015
Traffic engineering with traffic prediction is a promising approach to accommodate time-varying traffic without frequent route changes. In this approach, the routes are decided so as to avoid congestion on the basis of the predicted traffic. However, if the range of variation including temporal traffic changes within the next control interval is not ...
Tatsuya Otoshi, Yuichi Ohsita, Masayuki Murata 0001, Yousuke Takahashi, Keisuke Ishibashi, Kohei Shiomoto   +5 more
openaire   +1 more source

Traffic engineering with estimated traffic matrices

Proceedings of the 2003 ACM SIGCOMM conference on Internet measurement - IMC '03, 2003
Traffic engineering and traffic matrix estimation are often treated as separate fields, even though one of the major applications for a traffic matrix is traffic engineering. In cases where a traffic matrix cannot be measured directly, it may still be estimated from indirect data (such as link measurements), but these estimates contain errors.
Matthew Roughan, Mikkel Thorup, Yin Zhang 0001   +2 more
openaire   +1 more source

The Traffic Problem, Traffic Laws, and Traffic Courts

The ANNALS of the American Academy of Political and Social Science, 1953
At the end of 1952 the fatalities aggregated 38,000; nonfatal injuries 1,350,000; and property damage amounted to $3.5 million. Since the invention of the automobile, more than one million have lost their lives in traffic accidents. The millionth death occurred in December 1951.
openaire   +1 more source