Results 111 to 120 of about 1,347,636 (287)

Doxorubicin‐Loaded Metal–Organic Framework for Ferroptosis‐Enhanced Chemotherapy Through Sustained Zn Release and Glutathione Peroxidase Downregulation

Advanced Healthcare Materials, EarlyView.
A robust zinc‐based metal–organic framework (ZnMOF) enables dual functions of doxorubicin delivery and sustained Zn2+ release to trigger ferroptosis‐enhnaced chemotherapy. DOX@ZnMOF effectively depletes intracellular glutathione, suppresses GPX4, and elevates reactive oxygen species, leading to efficient oxidative DNA damage and apoptosis.
Xin Ma, Chenghua Deng, Chaoyu Wang, Langston Tilman, Jinhong Li, Wenbin Lin   +5 more
wiley   +1 more source

Air Traffic Control Safety Indicators: What is Achievable?

, 2006
European Air Traffic Control is extremely safe. The drawback to this safety record is that it is very difficult to estimate what the ‘underlying’ accident rate for mid-air collisions is now, or to detect any changes over time.
Brooker, Peter
core  

Targeting the ARRDC3–DRP1 Axis via hUMSC‐Derived Exosomal CRYAB for Neuroprotection in Cerebral Ischemia/Reperfusion Injury

Advanced Healthcare Materials, EarlyView.
Intranasally administered hUMSC‐derived exosomes modulate the CRYAB–ARRDC3–Drp1 axis, alleviating mitochondrial dysfunction and ferroptosis, enhancing neuronal survival, reducing oxidative stress, and promoting functional recovery in ischemia‐reperfusion injury, offering a promising therapeutic strategy for ischemic stroke.
Rong ji, Zengyu Zhang, Zhuohang Liu, Kaicheng Yang, Xueyu Mao, Min Chu, Yong Wang, Jing Zhao   +7 more
wiley   +1 more source

Enhanced Artificial Potential Field for Planning the Safe Return of Wartime Aircraft

Aerospace
In the wartime scenario of large-scale air combat, the battlefield situation is dynamically changing, and damaged aircraft often face issues such as limited maneuverability and fuel shortages.
Xuanmiao Sun, Di Shen, Fuping Yu, Xiaowei Niu   +3 more
doaj   +1 more source

Advances in Bioprinting to Model Immune‐Mediated Skin Diseases

Advanced Healthcare Materials, EarlyView.
This review explores how 3D bioprinting drives innovation in developing in vitro skin models that mimic immune‐mediated diseases. It highlights current technologies, key applications in studying skin pathologies, and emerging challenges. The review points toward future opportunities for improving disease modeling and advancing therapeutic and cosmetic ...
Andrea Ulloa‐Fernández, Marica Markovic, Julia Fernández‐Pérez, Georg Stary, Aleksandr Ovsianikov   +4 more
wiley   +1 more source

An optimized two‐phase demand‐responsive transit scheduling model considering dynamic demand

IET Intelligent Transport Systems
Demand‐responsive transit has gradually attracted attention in recent years for its flexibility, efficiency, and ability to meet the diverse travel demands of passengers.
Cui‐Ying Song, He‐Ling Wang, Lu Chen, Xue‐Qin Niu   +3 more
doaj   +1 more source

Research on Multi-Airspace Conflict Detection and Resolution Method Based on Octree Spatial Grid Partitioning

Aerospace
With the rapid development of the aviation industry, the complexity and intertwinement of various aviation activities have been continuously increasing, leading to the escalating of potential conflicts in limited airspace resources.
Qiang Li, Lujun Wan, Boyi Xiao, Yuqin Zhou   +3 more
doaj   +1 more source

AI-Enabled Traffic Control Prioritization in Software-Defined IoT Networks for Smart Agriculture. [PDF]

Sensors (Basel), 2023
Masood F, Khan WU, Jan SU, Ahmad J.
europepmc   +1 more source

Redefining Therapies for Drug‐Resistant Tuberculosis: Synergistic Effects of Antimicrobial Peptides, Nanotechnology, and Computational Design

Advanced Healthcare Materials, EarlyView.
Antimicrobial peptide (AMP)‐loaded nanocarriers provide a multifunctional strategy to combat drug‐resistant Mycobacterium tuberculosis. By enhancing intracellular delivery, bypassing efflux pumps, and disrupting bacterial membranes, this platform restores phagolysosome fusion and macrophage function.
Christian S. Carnero Canales, Jessica Ingrid Marquez Cazorla, Renzo Marianito Marquez Cazorla, Aline Martins dos Santos, Jonatas Lobato Duarte, Letícia Oliveira Catarin Nunes, Túlio Custódio Reis, Lara Cerazi Salvador, Norival Alves Santos‐Filho, Rafael Miguel Sábio, Hélder A. Santos, Fernando Rogério Pavan   +11 more
wiley   +1 more source

A Unified GNN-CV Framework for Intelligent Aerial Situational Awareness

Sensors
Aerial situational awareness (SA) faces significant challenges due to inherent complexity involving large-scale dynamic entities and intricate spatio-temporal relationships.
Leyan Li, Rennong Yang, Anxin Guo, Zhenxing Zhang   +3 more
doaj   +1 more source