Results 71 to 80 of about 101,188 (264)

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

Reconnaissance Mission Conducted by UAV Swarms Based on Distributed PSO Path Planning Algorithms

open access: yesIEEE Access, 2019
Reconnaissance mission has a wide application in both civil and military fields, which provides intelligence and basis for the following decision-making to accomplish certain goals.
Yubing Wang   +5 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Constrained Optimization and Dynamic Trade-Off Method for Formation Assignment of Heterogeneous UAV Swarms

open access: yesDrones
This paper addresses the formation assignment problem for heterogeneous UAV swarms in dynamic mission environments. A constrained optimization model is constructed in which UAV capabilities are divided into shareable and exclusive types; a neighborhood ...
Zhenxing Zhang   +5 more
doaj   +1 more source

From tumor‐centric to ecosystem‐based hypotheses in brain tumor research and care

open access: yesMolecular Oncology, EarlyView.
Primary brain tumors, whether in adults or children, present a major challenge because of their dramatic prognosis and the ongoing lack of efficient therapeutic approaches. In recent years, a shift has occurred from tumor‐centric concepts to a more holistic view of these tumors as dynamic ecosystems.
Julie Gavard   +8 more
wiley   +1 more source

Stochastic user equilibrium assignment with traffic-responsive signal control [PDF]

open access: yes
This paper considers the Stochastic User Equilibrium (SUE) assignment problem for a signal-controlled network in which intersection control is flow-responsive.
Claudio Meneguzzer
core  

Adaptive network traffic management for multi user virtual environments [PDF]

open access: yes, 2012
Multi User Virtual Environments (MUVE) are a new class of Internet application with a significant user base. This thesis adds to our understanding of how MUVE network traffic fits into the mix of Internet traffic, and how this relates to the application'
Oliver, Iain Angus
core  

Traffic particles and occurrence of acute myocardial infarction: a case-control analysis. [PDF]

open access: yes, 2009
OBJECTIVES: We modelled exposure to traffic particles using a latent variable approach and investigated whether long-term exposure to traffic particles is associated with an increase in the occurrence of acute myocardial infarction (AMI) using data from ...
Schwartz, Joel   +23 more
core   +1 more source

Optimal Sensor Deployment and Velocity Configuration With Hybrid TDOA and FDOA Measurements

open access: yesIEEE Access, 2019
Source localization based on the hybrid time-difference-of-arrival (TDOA) and frequency-difference-of-arrival (FDOA) measurements from distributed sensors is an essential problem in wireless sensor networks (WSNs).
Weijia Wang   +4 more
doaj   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

open access: yesFEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia   +3 more
wiley   +1 more source

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