Results 141 to 150 of about 836,306 (300)

Potent and Selective IGF‐IIR‐Recruiting Bifunctional Molecules for Targeted Lysosomal Degradation of Extracellular and Membrane Proteins

open access: yesAdvanced Science, EarlyView.
Lysosome‐targeting chimeras (LYTACs) enable degradation of extracellular and membrane proteins via lysosomal trafficking. We report a novel IGF‐II mutant (Del1–7, Y27L) that selectively engages IGF‐IIR while avoiding IGF‐IR and IR‐A. mutIGF‐II–based LYTACs enhance target internalization and degradation and support a genetically encodable, all‐protein ...
Yuan Zhao   +16 more
wiley   +1 more source

A Novel Entropy-Fuzzy PIPRECIA-DEA Model for Safety Evaluation of Railway Traffic [PDF]

open access: gold, 2020
Aleksandar Blagojević   +4 more
openalex   +1 more source

CD147/Basigin: From Integrative Molecular Hub to Translational Therapeutic Target

open access: yesAdvanced Science, EarlyView.
This review conceptualizes CD147 as a fundamental “Energy‐Structure Coupler,” physically bridging metabolic flux (via MCTs) with morphogenetic plasticity (via integrins/MMPs) to drive cancer, infection, and autoimmunity. Addressing the “specificity paradox” that limits current translation, the authors chart a strategic roadmap—spanning logic‐gated ...
Xiang‐Min Yang   +2 more
wiley   +1 more source

Intelligent Thermo‐Self‐Limited Magnetothermia with Heat‐Triggered TERT Silencing for Precision Synergetic Cancer Therapy

open access: yesAdvanced Science, EarlyView.
Telomerase reverse transcriptase (TERT) mRNA induces DNA self‐assembly in cancer cells, boosting the nanoplatform's magnetothermal properties. This magnetothermia then activates the Hsp70 promoter, initiating siRNA synthesis to silence the TERT gene, enhancing cancer treatment.
Liang Zhang   +9 more
wiley   +1 more source

The influence of heatwaves on traffic safety in five cities across Québec with different thermal landscapes. [PDF]

open access: yesInj Epidemiol
Nazif-Munoz JI   +5 more
europepmc   +1 more source

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