Results 121 to 130 of about 843,166 (295)

Study of Snow Accumulation on a High-Speed Train’s Bogies Based on the Discrete Phase Model

Journal of Applied Fluid Mechanics, 2017
During winters, the high-speed train travels in the northern of China is struck by to the snow, ice and coldness, massive snow accumulating on the bogies.
F. Xie, J. Zhang, G. Gao, K. He, Y. Zhang, J. Wang, Y. Zhang   +6 more
doaj  

Direct numerical simulation of supersonic boundary layer transition induced by gap-type roughness

Advances in Aerodynamics
The transition of the supersonic boundary layer induced by roughness is a highly intricate process. Gaining a profound understanding of the transition phenomena and mechanisms is crucial for accurate prediction and control.
Hongkang Liu, Kehui Peng, Yatian Zhao, Qian Yu, Zhiqiang Kong, Jianqiang Chen   +5 more
doaj   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Vaccine hesitancy was not shown to be associated with traffic safety or driver behavior. [PDF]

Front Public Health, 2023
Wilson J, Rinner C, Kone AP, Bosveld E.
europepmc   +1 more source

General aviation air traffic pattern safety analysis [PDF]

A concept is described for evaluating the general aviation mid-air collision hazard in uncontrolled terminal airspace. Three-dimensional traffic pattern measurements were conducted at uncontrolled and controlled airports.
Parker, L. C.
core   +1 more source

Cis‐ and Trans‐Regulatory Factors Independently Shape Phenotypic Heterogeneity of Retinitis Pigmentosa

Advanced Science, EarlyView.
A zebrafish model carrying an identical human RHO S334X allele reveals two independent genetic layers shaping retinitis pigmentosa (RP) severity: a protective 3‐bp cis‐regulatory insertion that attenuates transgene expression, and a dominant trans‐acting modifier that restores a severe phenotype.
Cong Cui, Kotone Nakagawa, Takumi Tateno, Ayaka Dan, Dexin Meng, Yoshihiro Omori, Soma Tomihara, Suzuri Okamoto, Shigeru Sato, Motokazu Tsujikawa   +9 more
wiley   +1 more source

Profiling Localized Immunomodulation and Drug Biodistribution within a Subcutaneous Vascularized Niche for Cell Transplantation

Advanced Science, EarlyView.
We studied how five common immunosuppressants behave when delivered directly to a transplant site instead of systemically. Using a vascularized implant for islet transplantation, we show that local delivery protects grafts, limits drug spread to the rest of the body, and produces distinct immune signatures.
Jocelyn Nikita Campa‐Carranza, Simone Capuani, Melissa A. Willman, Alexander Rabassa, Ashley L. Joubert, Tommaso Bo, Letizia Franco, Marzia Conte, Ana L. Anaya‐García, Gabrielle E. Rome, Rim Ouni, Henry J. Seaborne, Camden A. Caffey, Dora M. Berman, Junjun Zheng, Jesus Paez‐Mayorga, Corrine Ying Xuan Chua, Shu Hsia Chen, Norma S. Kenyon, Alessandro Grattoni   +19 more
wiley   +1 more source

Neutrophil‐Driven Cascade‐Targeted Nanocarriers Restore Mitochondrial Homeostasis to Ameliorate Renal Ischemia–Reperfusion Injury

Advanced Science, EarlyView.
A neutrophil‐mediated dual‐targeting liposome (NKN‐LNP) is developed to treat renal ischemia–reperfusion injury. The system enables spatiotemporally controlled delivery of NMN to injured tubules via MMP‐2/9 activation and KIM1 recognition, restoring mitochondrial function through NAD+‐SIRT3 signaling and preventing the transition from acute kidney ...
Hangbin Ma, Yang Li, Shen Lin, Feifan Chu, Gaozhan Ren, Yinhui Mao, Mingzhi Wu, Yuning Ma, Qiwei Ji, Zujie Chen, Jinzhong Ji, Mingxin Sun, Yongpeng Xu, Xiaoli Sun, Longguang Tang, Hao Zhou   +15 more
wiley   +1 more source

Performance evaluation of pretrained deep learning architectures for railway passenger ride quality classification

Alexandria Engineering Journal
This study investigates the performance of pretrained Convolutional Neural Networks (CNNs) in predicting passenger ride comfort classes based on encoded acceleration signal images.
Aliyu Kasimu, Wei Zhou, Qingkai Meng, Yazhao Wang, Zhixin Wang, Qiang Zhang, Yong Peng   +6 more
doaj   +1 more source

Automated Road Defect and Anomaly Detection for Traffic Safety: A Systematic Review. [PDF]

Sensors (Basel), 2023
Rathee M, Bačić B, Doborjeh M.
europepmc   +1 more source