Results 141 to 150 of about 2,998,717 (239)

Dual pKa Lipid Nanoparticles for Lung‐tropic mRNA Delivery and pH‐Programmed Endosomal Escape

open access: yesAdvanced Science, EarlyView.
Lipid nanoparticles’ bottleneck lies in low endosomal escape efficiency and liver‐dominant delivery after intravenous administration. To overcome these limitations, we present a stepwise pH‐programmed lipid nanoparticle system enabled by our newly synthesized ionizable lipid.
Seong Gi Lim   +12 more
wiley   +1 more source

The National Highway Traffic Safety Administration Traffic Safety Plan for Older Persons [PDF]

open access: yes
This 1993 research serves as a follow-up to the National Highway Traffic Safety Administration plan in 1988 that indicates that older drivers are overrepresented in crashes at intersections and during certain hours of the day, that they are ...
United States. Department of Transportation. National Highway Traffic Safety Administration
core  

Robust Localization and Tracking of VRUs with Radar and Ultra-Wideband Sensors for Traffic Safety. [PDF]

open access: yesSensors (Basel)
Raslan MA   +5 more
europepmc   +1 more source

Structural Basis of Shiga Toxin Neutralization by Human Antibodies Targeting Canonical Receptor‐Binding and Non‐Canonical Assembly Sites

open access: yesAdvanced Science, EarlyView.
Cryo‐electron microscopy structures reveal two distinct neutralization mechanisms of fully human monoclonal antibodies targeting the Shiga toxin 1a B subunit. RDS059 occludes the Gb3 receptor‐binding site, whereas RDS045 engages a lateral quaternary epitope to disrupt holotoxin assembly.
Jianting Ke   +10 more
wiley   +1 more source

Countermeasures That Work: A Highway Safety Countermeasure Guide for State Highway Safety Offices, 11th Edition, 2023 [PDF]

open access: yes
DTNH22-17-D-00042The guide is a basic reference to assist State Highway Safety Offices (SHSOs) in selecting effective, evidence-based countermeasures for traffic safety problem areas.
Kirley, Bevan   +9 more
core  

Assessing the impact of the national traffic safety campaign: a nationwide cohort study in Japan. [PDF]

open access: yesBMJ Open, 2022
Nakao S   +12 more
europepmc   +1 more source

Macrophage RSAD2 Couples mtDNA Synthesis With a Self‐Amplifying Inflammatory Circuit to Orchestrate Tissue Repair

open access: yesAdvanced Science, EarlyView.
Macrophage RSAD2 dually regulates CMPK2—the rate‐limiting enzyme for mitochondrial DNA synthesis—by suppressing its ubiquitination and promoting its phosphorylation via Csnk2a2 recruitment. This amplifies mtDNA production, which simultaneously activates a cGAS‐STING‐IRF3‐RSAD2 feedforward loop and the NLRP3 inflammasome, driving a self‐sustaining ...
Haomiao Yuan   +16 more
wiley   +1 more source

Examination of Traffic Safety in Neighborhoods Associated With Active Commuting to School in Austin, Texas. [PDF]

open access: yesJ Phys Act Health
Burford KG   +7 more
europepmc   +1 more source

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