Results 101 to 110 of about 3,227,928 (285)

Upadacitinib Restrains the Pathogenic Fitness of CD4+ T Cells and Aberrant B Cell Programming in Optic Neuritis

Advanced Science, EarlyView.
Single‐cell profiling and functional perturbation reveal coordinated JAK1‐pSTAT3 downstream programs in optic neuritis, including MCL1‐dependent fitness of pathogenic CD4+ Tem cells and glycolysis‐linked, cholesterol‐sensitive B‐cell responses associated with RORA. Upadacitinib disrupts this reciprocal T‐B‐cell circuit and alleviates neuroinflammation,
Gengchen Jiang, Qi Jiang, Lian Han, Yue Peng, Xingyu Liu, Tong Yang, Hao Huang, Jiaying Liu, Yuan Gao, Hui Yang, Wenjun Zou, Zhaohuai Li, Wenru Su   +12 more
wiley   +1 more source

Public transportation means as seen by citizens: Approaching the case of the Dominican Republic

Heliyon
Especially in low: and middle-income countries, key constraints such as dense traffic flows, jams, and pollution constitute frequent issues that potentially explain many negative consequences in terms of (e.g.) efficiency, sustainability, and mobility ...
Francisco Alonso, Cristina Esteban, Mireia Faus, Sergio A. Useche   +3 more
doaj   +1 more source

CRISPR and Gene Augmentation Rescue Trabecular Meshwork Dysfunction in iPSC Models of Lowe Syndrome

Advanced Science, EarlyView.
By modeling Lowe syndrome using patient‐derived iPSCs, this study establishes a human disease model that faithfully recapitulates OCRL deficiency‐associated ciliary and cytoskeletal defects. The model enables evaluation of both mutation‐agnostic DNA augmentation and CRISPR‐mediated mutation correction strategies, both of which restore OCRL function and
Siyu Chen, Zhiquan Liu, Wenmin Wang, Qing Wang, Tia J. Kowal, Fan Zhang, Grzegorz Walkiewicz, Faruk Hossen, Herbert M. Lachman, Jinqiong Zhou, Yiting Wang, Yang Sun   +11 more
wiley   +1 more source

Direct numerical simulation of supersonic boundary layer transition induced by gap-type roughness

Advances in Aerodynamics
The transition of the supersonic boundary layer induced by roughness is a highly intricate process. Gaining a profound understanding of the transition phenomena and mechanisms is crucial for accurate prediction and control.
Hongkang Liu, Kehui Peng, Yatian Zhao, Qian Yu, Zhiqiang Kong, Jianqiang Chen   +5 more
doaj   +1 more source

Crosswind-Induced Hazards of Railway Bridge Auxiliary Fixtures: An IDDES Study on Walkway Slabs and Cable Troughs

Applied Sciences
This study presents a comprehensive numerical investigation into the aerodynamic behavior of pedestrian walkway slabs and cable troughs mounted on high-speed railway bridges under crosswind conditions.
Hongkai Yan, Tanghong Liu, Xiaodong Chen, Haowei Cheng, Hongrui Gao, Xifeng Liang   +5 more
doaj   +1 more source

The review of traffic safety researches.

The Japanese journal of psychology, 1986
The traffic system has a multi-layered hierarchical structure. Traffic accidents are a phenomena on the man-machine system located at the middle level of the hierarchy. Focusing on this holon (man-machine system), safety problems are reviewed in relation with the upper and lower systems interacting with this holon.
openaire   +3 more sources

Beyond Biomimetics: Pathology‐Informed Engineering Rescues Reconstituted HDL From Inflammatory Dysfunction for Sepsis Immunotherapy

Advanced Science, EarlyView.
A pathology‐informed engineering strategy rescues reconstituted HDL from inflammatory dysfunction in sepsis. By integrating a ceria nanozyme‐celastrol coordination complex, the platform preserves HDL structure and endotoxin handling, sustains hierarchical intracellular delivery, and enhances immunoregulation across pathological models, translating ...
Han Zhou, Lei Zhang, Xingyu Cai, Jiajia Su, Guangyu Dai, Xue Chen, Hanming Wang, Jia Hua, Jianping Liu, Chunmeng Sun, Xiancheng Chen, Erhao Wang, Wenli Zhang   +12 more
wiley   +1 more source

Study of Snow Accumulation on a High-Speed Train’s Bogies Based on the Discrete Phase Model

Journal of Applied Fluid Mechanics, 2017
During winters, the high-speed train travels in the northern of China is struck by to the snow, ice and coldness, massive snow accumulating on the bogies.
F. Xie, J. Zhang, G. Gao, K. He, Y. Zhang, J. Wang, Y. Zhang   +6 more
doaj  

Magnetically Guided Macrophage Immunobots Coordinate Iron‐Metabolic Cascades and Immunogenic Ferroptosis for Tumor Immunotherapy

Advanced Science, EarlyView.
Magnetically guided macrophage immunobots integrate active tumor targeting with immunometabolic therapy. After systemic administration, magnetic actuation enhances immunobot retention and tumor penetration, while LPS‐functionalized FePt microrollers sustain M1‐like polarization through inflammatory and iron‐amplified oxidative signaling and trigger ...
Xirui Zeng, Yingfei Zhang, Chong Wu, Qijia Duan, Mengqi Fan, Kuan Wang, Shirong Cai, Immihan Ceren Yasa   +7 more
wiley   +1 more source

A report on the activities of the National Highway Traffic Safety Administration under the National Traffic and Motor Vehicle Safety Act of 1966.

, 1974
Issued also in the congressional series as a House document in a combined vol.
United States. National Highway Traffic Safety Administration.
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