Results 101 to 110 of about 166,211 (300)

Tumor‐Intrinsic ARHGEF3 Enhances Antitumor Immunity by Promoting T‐Cell Infiltration and Limiting Myeloid Cell‐Mediated Immunosuppression

Advanced Science, EarlyView.
ARHGEF3 is broadly downregulated across human cancers and correlates with patient prognosis. Tumor‐intrinsic ARHGEF3 activates the RHOA–ROCK–PTEN cascade to inhibit AKT signaling, thereby promoting chemokine‐driven T‐cell infiltration and relieving lipid‐mediated myeloid immunosuppression.
Yue Li, Lan Wang, Zihao Zhang, Chunmei Qian, Ning Li, Wei Huang, Qian Ba, Xiaojian Liu, Mayu Sun   +8 more
wiley   +1 more source

Public transportation means as seen by citizens: Approaching the case of the Dominican Republic

Heliyon
Especially in low: and middle-income countries, key constraints such as dense traffic flows, jams, and pollution constitute frequent issues that potentially explain many negative consequences in terms of (e.g.) efficiency, sustainability, and mobility ...
Francisco Alonso, Cristina Esteban, Mireia Faus, Sergio A. Useche   +3 more
doaj   +1 more source

Endogenous Engineering Reprograms Extracellular Vesicles for Enhanced Therapeutic Function

Advanced Science, EarlyView.
This review explains how Extracellular vesicles‐producing cells can be endogenously engineered to load therapeutic proteins and nucleic acids. We summarize physiological and genetic strategies that harness native sorting pathways for selective cargo loading.
Jinghui Wang, Wenxuan Zhao, Xiaoming Hu, Yishu Wang, Peidong Yang, Diwei Zheng, Yugang Wang, Guanghui Ma, Min Shi, Wei Wei, Shuang Wang   +10 more
wiley   +1 more source

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

Advanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale, Marie Celine Lefevre, Alessio Carmignani, Maria Cristina Ceccarelli, Matteo Battaglini, Attilio Marino, Gianni Ciofani   +6 more
wiley   +1 more source

Crosswind-Induced Hazards of Railway Bridge Auxiliary Fixtures: An IDDES Study on Walkway Slabs and Cable Troughs

Applied Sciences
This study presents a comprehensive numerical investigation into the aerodynamic behavior of pedestrian walkway slabs and cable troughs mounted on high-speed railway bridges under crosswind conditions.
Hongkai Yan, Tanghong Liu, Xiaodong Chen, Haowei Cheng, Hongrui Gao, Xifeng Liang   +5 more
doaj   +1 more source

Narcolepsy, Driving and Traffic Safety

, 2008
Driving ability in narcolepsy patients is often affected due to excessive daytime sleepiness and disturbed vigilance. Cataplexy and sleep paralysis may also play a role, but to a lesser extent. In this chapter, epidemiological evidence and experimental studies assessing driving performance in narcolepsy patients are discussed.
Donjacour, Claire E H M, Mets, Monique A J, Verster, Joris C.   +2 more
openaire   +2 more sources

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

Study of Snow Accumulation on a High-Speed Train’s Bogies Based on the Discrete Phase Model

Journal of Applied Fluid Mechanics, 2017
During winters, the high-speed train travels in the northern of China is struck by to the snow, ice and coldness, massive snow accumulating on the bogies.
F. Xie, J. Zhang, G. Gao, K. He, Y. Zhang, J. Wang, Y. Zhang   +6 more
doaj  

Tumor‐Induced Splenic Remodeling: Mechanisms of Systemic Immunosuppression and Emerging Therapeutic Opportunities

Advanced Science, EarlyView.
ABSTRACT Despite the transformative impact of cancer immunotherapies such as immune checkpoint blockade, durable clinical responses remain limited. Increasing evidence indicates that antitumor immunity is governed not only by the tumor microenvironment, but also by systemic immune regulation mediated by peripheral immune organs. Among these, the spleen
Yuehua Liu, Xiaoqian Nie, Xiaofei Gao
wiley   +1 more source

Direct numerical simulation of supersonic boundary layer transition induced by gap-type roughness

Advances in Aerodynamics
The transition of the supersonic boundary layer induced by roughness is a highly intricate process. Gaining a profound understanding of the transition phenomena and mechanisms is crucial for accurate prediction and control.
Hongkang Liu, Kehui Peng, Yatian Zhao, Qian Yu, Zhiqiang Kong, Jianqiang Chen   +5 more
doaj   +1 more source