Results 81 to 90 of about 843,166 (295)
Advanced Science, EarlyView.An autologous whole‐tumor‐cell vaccine (rWTC‐MBTA) is evaluated in murine CNS lymphoma. Subcutaneous vaccination activates dendritic cells, broadens T‐cell priming, and drives lymphocyte trafficking to brain tumors, producing durable tumor control. Longitudinal bioluminescence and adoptive‐transfer assays verify CNS engagement. Combination with anti‐PD‐
Yaping Zhang +10 more
wiley +1 more source
Numerical simulation of the aerodynamic characteristics of double unit train
Engineering Applications of Computational Fluid Mechanics, 2020 Double unit trains running at high speeds may create additional aerodynamic challenges due to two streamlined structures with close proximity, exploring the aerodynamic performance of double unit trains is now critical.
Zijian Guo +4 more
doaj +1 more source
Traffic Safety and Vehicle Choice: Quantifying the Effects of the "Arms Race" on American Roads [PDF]
The increasing market share of light trucks in the U.S. in recent years has been characterized as an “arms race” where individual purchase of light trucks for better self-protection in collisions nevertheless leads to worse traffic safety for the society.
Li, Shanjun
core
TEAD1 Enhances Exosome Secretion and Promotes Exosome‐Mediated Tissue Regeneration
Advanced Science, EarlyView.TEAD1 functions as a crucial molecular switch regulating exosome secretion in various cell types. TEAD1 enhances exosome secretion by upregulating key proteins associated with exosome secretion, including RAB11, CD9, and SNAP23. This study reveals a novel role for TEAD1 in regulating exosome secretion and tissue regeneration, particularly in diabetic ...
Yan Pu +9 more
wiley +1 more source
Advanced Science, EarlyView.This study introduces Cadict, an EGFR‐targeted nanodrug that co‐delivers cuproptosis and disulfidptosis inducers to overcome immune resistance. Cadict synergistically enhances tumor cytotoxicity and sensitizes cancers to ICIs by upregulating PD‐L1 via an Eif5b‐dependent translation mechanism, fostering a potent antitumor immune response and ...
Shaoqing Huang +12 more
wiley +1 more source
Numerical Simulation with a DES Approach for a High-Speed Train Subjected to the Crosswind
Journal of Applied Fluid Mechanics, 2017 A Detached Eddy Simulation (DES) method based on the SST k-ω turbulence model was used to investigate the instantaneous and time-averaged flow characteristics around the train with a slender body and high Reynolds number subjected to strong crosswinds ...
J. Zhang +4 more
doaj
Simulation And Analysis Of Indian Air Traffic [PDF]
, 2005 Air Traffic Density In India And The World At Large Is Growing Fast . The Airspace And Air Traffic Management Therefore Need Augmentation Of System Capability Without Compromising Safety .
Lathasree, P +2 more
core
, 2009 This paper illustrates a methodology developed to analyze the influence of traffic conditions, i.e. volume and composition on accidents on different types of interurban roads in Spain, by applying negative binomial models.
A. Gómez Méndez +17 more
core +1 more source
Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy
Advanced Science, EarlyView.Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong +5 more
wiley +1 more source
β‐Triketone‐Based Ionizable Cationic Lipids Synthesized via Click Chemistry for siRNA Delivery
Advanced Science, EarlyView.This study innovatively applies β‐triketone‐based click chemistry in the synthesis of ionizable cationic lipids (ICLs), which allows the generation of a lipid library in large quantities and in a short time. The ICLs identified achieved effective lipid nanoparticles‐mediated hepatic gene silencing in vivo using siRNA, and computational simulations are ...
Huatian Li +7 more
wiley +1 more source