Results 91 to 100 of about 843,166 (295)

Understanding and Overcoming Antibody‐Drug Conjugate Resistance: Biological Mechanisms and Emerging Analytical Frameworks in Breast Cancer

Advanced Science, EarlyView.
Antibody–drug conjugates (ADCs) transform breast cancer therapy, yet resistance limits their durability. Emerging evidence reveals that ADC failure is not solely tumor‐intrinsic but shaped by dynamic tumor–microenvironment interactions that alter drug delivery, processing, and response.
Minji Seo, Jangsoon Lee, Naoto T. Ueno
wiley   +1 more source

Traffic Safety [PDF]

Injury Prevention, 2005
  +5 more sources

Problems for Vulnerable Road Users in the Netherlands [PDF]

, 1989
INTRODUCTION In the Netherlands pedestrian and pedal cycle travel are important transport modes for the population. However, given the particularly vulnerable nature of these modes of transport, pedestrians and cyclists are involved in a large number ...
Rothengatter, J.A., van Shagen, I.N.L.G.
core  

Time‐Controlled Refrigerated Stem Cell Therapy Mitigates Scleroderma Fibrosis via Modulation of Mitochondrial Autophagy and Gut Metabolism

Advanced Science, EarlyView.
This study established an RT‐MSCs‐based therapeutic approach for scleroderma in mice. RT‐MSCs attenuated fibrosis by regulating mitochondrial autophagy and restored gut microbiota homeostasis. Metabolomic analyses confirmed recovery of key metabolites, and RT‐MSCs demonstrated favorable lesion targeting and safety profiles.
Xue Xia, Chenfei Kong, Xiaoming Zhao, Naixu Shi, Jinlan Jiang, Ping Li   +5 more
wiley   +1 more source

Numerical simulation of the effect of projectile shape and size on the high-velocity impact of carbon fiber reinforced composite laminates

Journal of Materials Research and Technology
To investigate the impact response and damage mechanism of CFRP composite materials for high-speed trains under high-speed impact from foreign objects of different shapes and sizes, high-speed impact experiments and simulations were conducted on CFRP ...
Yong Peng, Xin Wang, Xuanzhen Chen, Kui Wang, Zhiqiang Huang, Zhixiang Liu, Honghao Zhang   +6 more
doaj   +1 more source

Patterns on Work-Related Stress and Tobacco Consumption in City Bus Drivers

SAGE Open, 2018
Work-related stress and addictive behaviors have been described by several empirical studies as potential impairers for the health, welfare, and safety of workers.
Sergio A. Useche, Natura Colomer, Francisco Alonso, Luis Montoro   +3 more
doaj   +1 more source

Activated Platelet–Released Heat Shock Protein 90α Triggers Autophagy‐Dependent Neutrophil Extracellular Trap Formation and Amplifies Sepsis

Advanced Science, EarlyView.
HSP90α is significantly upregulated in platelets from sepsis patients, with its origin from megakaryocyte‐derived trafficking. Furthermore, activated platelets secrete HSP90α into the extracellular space in both free and exosome‐associated forms. Finally, extracellular HSP90α directly engages TLR4 on neutrophils to induce autophagy, leading to NET ...
Chengbo Wang, Maodong Leng, Chenchen Sun, Jingyu Cao, Linfei Li, Yangyang Jia, Yongshuai Han, Yuchun Liu, Yaodong Zhang, Chenglong Zhang, Yingli Men, Ningyuan Liu, Yibing Cheng, Yixia Zhang, Ya Li, Zhenlong Li, Lidan Cui, Xiangzhan Zhu   +17 more
wiley   +1 more source

A Nanoparticle‐Integrated Complete Manufacturing Pipeline of Chemically Engineered Exosomes

Advanced Science, EarlyView.
We report a novel manufacture technology of chemically engineered exosomes. The four steps of manufacturing, i.e., biogenesis, loading, isolation, and storage, are integrated by the use of a nanoparticle. The manufacture technology incorporates three innovative components, i.e., a new nano‐bio effect, a new composite nanoparticle, and a new isolation ...
Xiaowei Wen, Zixing Xu, Zerun Hao, Yanming Chen, Kai Xie, Haofan Yin, Xueying Wang, Jie Min, Sihan Sun, Baiding Chen, Chengxiu Ling, Mingming Xu, Yizhao Chen, Gang Ruan   +13 more
wiley   +1 more source

Red ink in the rearview mirror: local fiscal conditions and the issuance of traffic tickets [PDF]

Municipalities have revenue motives for enforcing traffic laws in addition to public safety motives because many traffic offenses are punished via fines and the issuing municipality often retains the revenue.
Gary A. Wagner, Thomas A. Garrett
core  

Multi-objective road pricing: a cooperative and competitive bilevel optimization approach [PDF]

, 2010
Costs associated with traffic externalities such as congestion, air pollution, noise, safety, etcetera are becoming unbearable. The Braess paradox shows that combating congestion by adding infrastructure may not improve traffic conditions, and ...
Berkum, Eric van, Bliemer, Michiel, Ohazulike, Anthony, Still, Georg   +3 more
core   +1 more source