Results 181 to 190 of about 2,998,717 (239)

Can Chemoradiotherapy Expand Immune Checkpoint Blockade Responsiveness in Mismatch Repair‐Proficient Rectal Cancer?

open access: yesAnnals of Gastroenterological Surgery, EarlyView.
ABSTRACT Immune checkpoint blockade (ICB) has transformed the treatment of mismatch repair‐deficient (dMMR) colorectal cancer but produces no meaningful benefit in advanced mismatch repair‐proficient (pMMR) disease. In the neoadjuvant setting, however, pathological responses have been reported in a subset of pMMR tumors, suggesting that clinical ...
Kimihiro Yamashita   +4 more
wiley   +1 more source

Accelerating Primary Screening of USP8 Inhibitors from Drug Repurposing Databases with Tree‐Based Machine Learning

open access: yesAdvanced Intelligent Discovery, EarlyView.
This study introduces a tree‐based machine learning approach to accelerate USP8 inhibitor discovery. The best‐performing model identified 100 high‐confidence repurposable compounds, half already approved or in clinical trials, and uncovered novel scaffolds not previously studied. These findings offer a solid foundation for rapid experimental follow‐up,
Yik Kwong Ng   +4 more
wiley   +1 more source

Developing a national road traffic safety education program in Iran. [PDF]

open access: yesBMC Public Health, 2020
Bakhtari Aghdam F   +6 more
europepmc   +1 more source

Toward Complex In‐Car Environment Human–Vehicle Interactions Through Smart Glasses and sEMG‐Based Gesture Recognition

open access: yesAdvanced Intelligent Systems, EarlyView.
This study proposes a novel weighted random forest multimodal fusion method that combines smart glasses and sEMG data for in‐vehicle gesture interaction. It realizes stable performance in dim, occluded, and other constrained scenarios, providing feasible solutions and laying a foundation for universal human–machine interaction.
Wenbo Zhang   +8 more
wiley   +1 more source

PERSIAN traffic safety and health cohort: a population-based precrash cohort study. [PDF]

open access: yesBMJ Open
Golestani M   +15 more
europepmc   +1 more source

Interpretable Short‐Term Electric Load Forecasting

open access: yesAdvanced Intelligent Systems, EarlyView.
A temporal fusion transformer is implemented to generate day‐ahead forecasts of the hourly electrical load of a departmentbuilding at an Italian university. A forecasting performance improvement of more than 25% compared with established benchmark models and a provision of inherent robust interpretability insights reveal the potential of this model for
Alessandro Nicola   +6 more
wiley   +1 more source

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