Results 31 to 40 of about 3,227,928 (285)

Crashworthiness analysis and structural optimization of shrink tube under interference condition

Engineering Science and Technology, an International Journal, 2023
This paper aims to study the crashworthiness of shrink tubes for rail vehicles under axial impact loading. A theoretical model of shrink tube for platform force prediction under interference fit conditions was proposed. The trolley crash test was used to
Ping Xu, Yuhui Yang, Chengxing Yang, Shuguang Yao, Jie Xing, Fan Zou   +5 more
doaj   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Development and research of a SS-level universal double-beam assembled bridge barrier

Scientific Reports
A wide variety of bridge barriers are used on highways. The bearing capacities of different types of deck slabs are measured in this study by applying the yield line theory to determine the worst-case scenario.
Qianmiao Bu, Xinpeng Ning, Wen Zhang, Lei Ma   +3 more
doaj   +1 more source

Severity of cyclist head injuries caused by impacts with vehicle structure and road surface

Journal of Biomechanical Science and Engineering, 2016
For cyclist fatalities in 2014 in Japan, the head was the most frequently injured body region. In the present study, the authors analyzed the features of cyclist head injuries in real-world traffic accidents using the data of patients who were taken to ...
Shoko OIKAWA, Yasuhiro MATSUI, Asato WAKABAYASHI, Sayaka GOMEI, Hiromichi NAKADATE, Shigeru AOMURA   +5 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Research on the failure mechanism and enhanced energy-absorbing capacity for a novel concave octagonal NPR honeycomb structure

Scientific Reports
The increasing demand for lightweight and safe rail transit structures has highlighted negative Poisson’s ratio (NPR) honeycombs as promising energy-absorbing architectures due to their superior failure mechanism and crashworthiness.
Chengxing Yang, Yuan Zhong, Yiyang Ma, Yujia Huo, Zhao Nan, Jun Yang, Xifeng Liang   +6 more
doaj   +1 more source

Numerical Study on the Aeroacoustic Performance of Different Diversion Strategies in the Pantograph Area of High-Speed Trains at 400 km/h

Applied Sciences, 2022
The speed increase in high-speed trains is a critical procedure in the promotion of high-speed railway technology. As an indispensable and complex structure of high-speed trains, the pantograph’s aerodynamic drag and noise is a significant limitation in ...
Hongkang Liu, Siqi Zhou, Rongrong Chen, Zhuolun Li, Shishang Zhang, Yatian Zhao   +5 more
doaj   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Dynamical Behavior of Fractional-Order Delayed Feedback Control on the Mathieu Equation by Incremental Harmonic Balance Method

Shock and Vibration, 2022
In this study, the dynamical analysis of the Mathieu equation with multifrequency excitation under fractional-order delayed feedback control is investigated by the incremental harmonic balance method (IHBM).
Shaofang Wen, Yongjun Shen, Jiangchuan Niu, Yunfei Liu   +3 more
doaj   +1 more source