Results 41 to 50 of about 2,998,717 (239)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Applied Sciences, 2022 The speed increase in high-speed trains is a critical procedure in the promotion of high-speed railway technology. As an indispensable and complex structure of high-speed trains, the pantograph’s aerodynamic drag and noise is a significant limitation in ...
Hongkang Liu +5 more
doaj +1 more source
Protocol for quantifying miRNA trafficking across the endosomal membrane
FEBS Open Bio, EarlyView.An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh +2 more
wiley +1 more source
Development and research of a SS-level universal double-beam assembled bridge barrier
Scientific ReportsA wide variety of bridge barriers are used on highways. The bearing capacities of different types of deck slabs are measured in this study by applying the yield line theory to determine the worst-case scenario.
Qianmiao Bu +3 more
doaj +1 more source
Severity of cyclist head injuries caused by impacts with vehicle structure and road surface
Journal of Biomechanical Science and Engineering, 2016 For cyclist fatalities in 2014 in Japan, the head was the most frequently injured body region. In the present study, the authors analyzed the features of cyclist head injuries in real-world traffic accidents using the data of patients who were taken to ...
Shoko OIKAWA +5 more
doaj +1 more source
FEBS Open Bio, EarlyView.TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao +10 more
wiley +1 more source
Scientific ReportsThe increasing demand for lightweight and safe rail transit structures has highlighted negative Poisson’s ratio (NPR) honeycombs as promising energy-absorbing architectures due to their superior failure mechanism and crashworthiness.
Chengxing Yang +6 more
doaj +1 more source
Mathematics, 2023 In the Dempster–Shafer evidence theory framework, extremum analysis, which should be repeatedly executed for uncertainty quantification (UQ), produces a heavy computational burden, particularly for a high-dimensional uncertain system with multiple joint ...
Shengwen Yin +4 more
doaj +1 more source
Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw +5 more
wiley +1 more source