Results 191 to 200 of about 10,613 (255)

Dual Covalent Targeting of STING Cysteines 292/309 Disrupts Functional Oligomerization and Enables Potent Antagonist Development

Advanced Science, EarlyView.
We report a rational design strategy for STING antagonists by dual covalent targeting of Cys292/309 in its C‐terminal domain, directly preventing functional oligomerization. Through covalent warhead repurposing, we identified P005091 and revealed its unique dual‐cysteine mechanism.
Yuxuan Zhao, Ling Huang, Wenjing Qin, Bin Zhang, Yang Yang, Xue Chen, Xiaoquan Wang, Weilin Zhou, Feiyang Chen, Zhenyu Li, Liyuan Le, Yiqiu Zhang, Zhen Xiang, Lu Zhang, Fei Wang, Dan Lei, Zi‐zhe Cai, Ying Gao, Yong Chen, Xuecen Wang, Junmin Quan, Shuixing Zhang, Xianzhang Bu, Xin Yue   +23 more
wiley   +1 more source

Traffic pattern-adaptive channel allocation in cognitive radio networks via multi-scale windowing. [PDF]

Sci Rep
Min Z, Ziru W, Jinyuan B, Bo Z.
europepmc   +1 more source

Nanomedicine Meets Immunotherapy: Advancing Adoptive Cell Therapy with Nanoparticles in the Treatment of Cancer with Sustainability Perspectives

Advanced Science, EarlyView.
This review surveys nanoparticle‐based strategies to enhance adoptive cell therapy, particularly CAR‐T cell approaches, in solid tumor treatment. It describes how nanoparticles can improve tumor immunogenicity and T‐cell infiltration while reducing toxicity, and how they enable in vivo CAR‐T cell generation.
Erica Frostegård, Tatiana Bobrova, Amalie Leinebø, Thibault Leray, Shayamita Ghosh, Lorena García‐Hevia, Chiara Puccinelli, Lorenzo Riccio, Jacopo Sorani, Davide Bonifazi, Julien Caumartin, Emmanuel Donnadieu, Florence Gazeau, Roland Hischier, Else Marit Inderberg, Mónica L. Fanarraga, Maria Loustau, Bernd Nowack, Sébastien Wälchli, Cécilia Ménard‐Moyon   +19 more
wiley   +1 more source

Enhancing Flight Connectivity via Synchronization of Arrivals and Departures in Hub Airports with Evolutionary and Swarm-Based Metaheuristics. [PDF]

Biomimetics (Basel)
Demir HI, Dervis S.
europepmc   +1 more source

Dynamic Shifts in ER–Plasma Membrane Junctions Signaling Define Pro‐Metastatic N‐Glycosylation and Predict Prostate Cancer Progression

Advanced Science, EarlyView.
Prostate cancer remains a leading cause of male cancer death, yet screening cannot reliably identify aggressive disease, underscoring the need for tissue biomarkers. It is shown that primary tumors increase ER–plasma membrane junction signaling via STIM1/ORP5, whereas metastasis features their loss, Golgi dispersal, and rapid conversion of high‐mannose
Amanda J. Macke, Tania Kamal, Taylor E. Divita, Artem N. Pachikov, Chad A. LaGrange, Rajesh Ravichandran, Martha Morton, Robert Powers, Haowen Qiu, Jean‐Jack M. Riethoven, Colm Morrissey, Melinda Wojtkiewicz, Rebekah L. Gundry, Carol A. Casey, Armen Petrosyan   +14 more
wiley   +1 more source

A Hybrid Optimization Algorithm for Enhancing Transportation and Logistics Scheduling in IoT-Enabled Supply Chains. [PDF]

Sensors (Basel)
Jihad AA, Abdalkafor AS, Yassen ET, Aldhaibani OA.   +3 more
europepmc   +1 more source

Energy efficient UAV-assisted two layer hierarchical bit-mapping access based MAC protocol. [PDF]

Sci Rep
Narayan Golatkar D, Tolani M, Pai SN, Vilas Mahadik Y, Kumar P, Suman G.   +5 more
europepmc   +1 more source

Reliable Communication in Distributed Photovoltaic Sensor Networks: A Large Language Model-Driven Approach. [PDF]

Sensors (Basel)
Dong W, Liu X, Liu Q, Zhang G, Shi J, Zhao X, Lei Z, Wang W.   +7 more
europepmc   +1 more source

Unsignalized intersection vehicle platoon formation scheduling method based on mixed traffic. [PDF]

Sci Rep
Jiang J, Rui Y, Ran B.
europepmc   +1 more source

Power Control in Wireless Body Area Networks: A Review of Mechanisms, Challenges, and Future Directions. [PDF]

Sensors (Basel)
Su H, Zhao Z, Gu B, Lin S.
europepmc   +1 more source