Results 71 to 80 of about 457,315 (281)

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Day/night variations of myeloid and lymphoid cell subsets in the murine inguinal lymph node

FEBS Open Bio, EarlyView.
The circadian system is involved in the temporal regulation of the immune system. Our study reveals that two innate immune populations, NKT cells and neutrophils, predominate at the beginning of the day in healthy mice, highlighting how the time of day influences immune responses.
Paula M. Wagner, César G. Prucca, Lucia Boffelli, Virginia A. Piqueras, Silvia G. Correa, Mariana Maccioni, Mario E. Guido   +6 more
wiley   +1 more source

Assessment of different urban traffic control strategy impacts on vehicle emissions [PDF]

, 2015
This paper investigates the influence of traffic signal control strategy on vehicle emissions, vehicle journey time and total throughput flow within a single isolated four-armed junction.
Han, K, Hu, J, Luan, J, Mascia, M, North, R, Thiyagarajah, A   +5 more
core  

Autophagosome marker, LC3, is released extracellularly via several distinct pathways

FEBS Open Bio, EarlyView.
This study establishes a novel HiBiT‐tagging system for ultrasensitive detection of LC3, revealing multiple pathways for its extracellular secretion. It demonstrates that LC3 is released via both autophagy‐dependent and ‐independent mechanisms, including a novel route for nonlipidated LC3‐I.
Koki Saito, Masashi Arakawa, Koki Maeda, Eiji Morita   +3 more
wiley   +1 more source

CoLight: Learning Network-level Cooperation for Traffic Signal Control

, 2019
Cooperation among the traffic signals enables vehicles to move through intersections more quickly. Conventional transportation approaches implement cooperation by pre-calculating the offsets between two intersections.
Chen, Chacha, Li, Zhenhui, Wei, Hua, Xu, Kai, Xu, Nan, Zang, Xinshi, Zhang, Huichu, Zhang, Weinan, Zheng, Guanjie, Zhu, Yanmin   +9 more
core   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Software-defined Architecture for Urban Regional Traffic Signal Control

Promet (Zagreb), 2020
Regional Traffic Signal Control (RTSC) is believed to be a promising approach to alleviate urban traffic congestion. However, the current ecology of RTSC platforms is too closed to meet the needs of urban development, which has also seriously affected ...
Songhang Chen, Dan Zhang, Fenghua Zhu
doaj   +1 more source

Using Automated Planning for Traffic Signals Control

Promet - Traffic&Transportation, 2016
Solving traffic congestions represents a high priority issue in many big cities. Traditional traffic control systems are mainly based on pre-programmed, reactive and local techniques. This paper presents an autonomic system that uses automated planning techniques instead.
Matija Gulić, Ricardo Olivares, Daniel Borrajo   +2 more
openaire   +4 more sources

Frame Structure Design and Analysis for Millimeter Wave Cellular Systems

, 2016
The millimeter-wave (mmWave) frequencies have attracted considerable attention for fifth generation (5G) cellular communication as they offer orders of magnitude greater bandwidth than current cellular systems.
Dutta, Sourjya, Ford, Russell, Mezzavilla, Marco, Rangan, Sundeep, Zhang, Menglei, Zorzi, Michele   +5 more
core   +1 more source

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source