Results 91 to 100 of about 10,472,101 (345)

Copper‐Driven Epithelial Barrier Disruption: A Novel Mechanism of COPD Acute Exacerbations Mediated by the TNF‐α/ATP7A Axis

Advanced Science, EarlyView.
This study reveals a copper‐driven mechanism of COPD acute exacerbations mediated by the TNF‐α/ATP7A axis. TNF‐α suppresses the copper transporter ATP7A via competitive NF‐κB/CREB1/CBP signaling, resulting in intracellular copper accumulation, mitochondrial oxidative stress, and epithelial barrier disruption.
Xinru Xiao, Yongzhe Hao, Ziqi Ding, Zhipeng Wang, Yujia Shi, Yanhua Huang, Chunjian Qi, Qian Zhang   +7 more
wiley   +1 more source

Traffic Flow Simulator by Multiagent

Journal of Robotics and Mechatronics, 2001
Several methods have been proposed for investigating complex traffic flows. However, the dynamics of vehicles and their drivers' characteristics, which are important factors for any traffic flow analysis, have not been considered sufficiently enough in the past. This paper describes a new concept for simulating complex traffic flows by multiple agents.
Hitoshi Tsunashima, Yasukazu Nishi, Takashi Honjyo, Hiroyuki Kaku, Takuji Sakai   +4 more
openaire   +1 more source

Automatic Generation of Open Data-Based Traffic Simulation Model

IEEE Access
Open transportation data is becoming more accessible, creating new opportunities for data-driven traffic simulation. However, transforming this data into a simulation-ready model is complex and time-consuming. This study introduces an automated framework
Hyunyoung Ryu, Jitaek Lim, Minseok Song
doaj   +1 more source

BAP31 Drives Cartilage Calcification through Disruption of Autophagosome–Lysosome Fusion in Osteoarthritis

Advanced Science, EarlyView.
Mechanical stress activates BAP31 in chondrocytes. BAP31 competes with ATG14 for binding to STX17, disrupting the STX17–ATG14 complex required for autophagosome–lysosome fusion. The resultant autophagic flux blockade drives the generation of autophagy‐derived exosomes, which mediate pathological cartilage calcification in OA. Chondrocyte‐targeted BAP31
Zhi‐hua Xu, Ruo‐xin Wang, Feng He, Qian Liu, Fu‐yin Li, Min Hui, Yu‐qian Shi, Yu Jiang, Qing‐hua Li, Jun‐wen Jing, Shi‐bin Yu, Li‐tian Ma, Qian‐nan Niu, Mian Zhang   +13 more
wiley   +1 more source

Calibration of microscopic traffic simulation models using metaheuristic algorithms

, 2017
This paper presents several metaheuristic algorithms to calibrate a microscopic traffic simulation model. The genetic algorithm (GA), Tabu Search (TS), and a combination of the GA and TS (i.e., warmed GA and warmed TS) are implemented and compared. A set
Yu Miao, W. Fan
semanticscholar   +1 more source

Calibration and validation of large-scale traffic simulation networks: a case study

ANT/SEIT, 2018
The availability, accuracy and relevance of real world input data are essential for developing a reliable traffic simulation model. Large-scale traffic simulation models, in particular, require data from many sources and in great detail. Though it is now
Bekir Bartin, K. Ozbay, Jingqin Gao, Abdullah Kurkcu   +3 more
semanticscholar   +1 more source

An On‐Demand Neuromorphic Vision System Enabled by a Multi‐Paradigm Neuromorphic Device and Hierarchical Reconfigurability Designed from Device to System Level

Advanced Science, EarlyView.
An on‐demand ultra‐reconfigurable intelligent vision system with hierarchical reconfigurability from device to system levels is demonstrated. Through co‐design of a multi‐paradigm device, reconfigurable circuits, and adaptive system architecture/algorithms, the system enables seamless switching among spiking, non‐spiking, neuromorphic imaging (NI), and
Biyi Jiang, Jiayi Xu, Liang Ran, Xinhe Feng, Khalil Harrabi, Yida Li, Longyang Lin, Feichi Zhou   +7 more
wiley   +1 more source

Evaluation of City Planning Road Development Measures by Microscopic Traffic Simulation [PDF]

This study was made on the development plan of Kawahara Avenue, a road project authorized in city planning of Miyazaki City in Japan. The Kawahara Avenue development is planned along the Oyodo River. The land use of the area along the route comprises the
Tetsunobu Yoshitake, Masaya Kawano, Satoshi Toi, Hiroshi Tatsumi, Yoshitaka Kajita   +4 more
core  

Charting Endocrine Progenitors Across Species and Organs

Advanced Science, EarlyView.
Endocrine progenitors give rise to the hormone‐producing cells of the pancreas and intestine. Using single‐cell multiomics and proteomics, this study compares these progenitors across species, systems, and organs, mapping the conserved and species‐specific gene regulatory networks that guide their formation.
Changying Jing, Michael Sterr, Özüm Sehnaz Caliskan, Lama Saber, Nicole Katarina Rogers, Samuel Ogden, Kei Kozawa, Christos Karampelias, Jessica Jaki, Aimée Bastidas‐Ponce, Falk Janos Farkas, Oliver Czarnecki, Osvaldo Rodrigues Pereira, Perla Cota, Valerie Vandenbempt, Diego Balboa, Anika Böttcher, Natalie Krahmer, Mohammad Lotfollahi, Julie B. Sneddon, Heiko Lickert, Mostafa Bakhti   +21 more
wiley   +1 more source

Exploring Execution Schemes for Agent-Based Traffic Simulation on Heterogeneous Hardware

IEEE International Symposium on Distributed Simulation and Real-Time Applications, 2018
Microscopic traffic simulation is associated with substantial runtimes, limiting the feasibility of large-scale evaluation of traffic scenarios. Even though today heterogeneous hardware comprised of CPUs, graphics processing units (GPUs) and fused CPU ...
Jiajian Xiao, Philipp Andelfinger, D. Eckhoff, Wen-Tong Cai, A. Knoll   +4 more
semanticscholar   +1 more source