Results 111 to 120 of about 813,117 (289)

A Single‐Amino‐Acid Ligand for LAT1: A Minimalist and Modular Platform for Lysosome‐Targeted Degradation of Membrane Proteins

Advanced Science, EarlyView.
LA‐LYTAC repurposes the cancer‐enriched amino acid transporter LAT1 as a lysosomal trafficking receptor for targeted membrane‐protein degradation. A single phenylalanine‐derived ligand, modularly linked to antibodies or small‐molecule binders, recruits PD‐L1, EGFR, or integrins to LAT1, triggering transporter‐mediated internalization, lysosomal ...
Liquan Zhu, Ke Liu, Haotian Liu, Chaoqi He, Xiaozhen Liu, Xin Zeng, Misha Mao, Yuxiao Mu, Ying Li, Qinghui Zheng, Hongchao Tang, Da Qian, Xuli Meng   +12 more
wiley   +1 more source

Lipidomic Profile Reconstruction of Therapeutic Membrane Targets Using Physics‐Based Optimization with Limited Activity Data

Advanced Science, EarlyView.
Using a minimal set of experimentally labeled antimicrobial and non‐antimicrobial peptides, we reconstruct the effective lipid composition of a pathogenic membrane ‐demonstrated at the example of bacterial membranes‐ through a physics‐based evolutionary molecular dynamics (Evo‐MD) approach. Optimization based on peptide insertion reveals broad‐spectrum
Maximilian Krebs, Herre Jelger Risselada
wiley   +1 more source

Integrated regional resilience assessment platform for interdependent systems

Resilient Cities and Structures
Computer simulations are critical for assessing the resilience of civil infrastructure to natural hazards. To support efficient and comprehensive analyses that account for interdependencies among infrastructure systems, an integrated platform that spans ...
Jinyan Zhao, Nikola Blagojević, Sina Naeimi, Barbaros Cetiner, Tianyu Han, Frank McKenna, Božidar Stojadinović, Matthew Dejong   +7 more
doaj   +1 more source

A Guide for Traffic Safety Practitioners: Best Practices for Increasing Seat Belt Use in Rural Communities [Traffic Tech] [PDF]

This edition of Traffic Tech brief describes the four major components of NHTSA\u2019s forthcoming report, A Guide for Traffic Safety Practitioners: Best Practices for Increasing Seat Belt Use in Rural Communities.
United States. Department of Transportation. National Highway Traffic Safety Administration. Office of Impaired Driving and Occupant Protection
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Automated creation of traffic in scenarios for driving simulators [PDF]

, 2019
Předmětem diplomové práce "Automatická tvorba provozu ve scénářích pro vozidlové simulátory" je vytvořit metodu automatického vytváření všech souborů potřebných k definici animace pro snadné a rychlé generování provozu do scénářů pro vozidlové simulátory.
Klára Pudová
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Matrix Stiffness Enhances Odontogenic Differentiation of DPSCs through Membrane Curvature Protein Baiap2‐Modulated Exosome Release

Advanced Science, EarlyView.
Matrix stiffness softening is identified as a previously underappreciated feature in deep caries. Higher stiffness drives exosome release in dental pulp stem cells through a coordinated mechanism involving PI3K–AKT‐regulated Baiap2 and kinesin‐1, thereby promoting odontogenic differentiation.
Bilun Jin, Shaojie Dong, Yue Jia, Zhao Xu, Peiqi Liu, Zhaojing Ding, Yuxin Liao, Rui Zou, Jinsong Hu, Bo Cheng, Lin Niu   +10 more
wiley   +1 more source

Laptop-scale benchmark of BlockSim, Simewu, and IOTA hornet for network practitioners

Discover Computing
Open-source simulators let engineers stress-test blockchain ideas long before field deployment, yet few studies compare tools side-by-side. This tutorial article benchmarks two research-grade simulators, namely, BlockSim and Simewu, and the production ...
Jose Almarcha-Sanchez, Maria-Jesus Alba-Baena, Volodymyr Dubetskyy, Maria-Dolores Cano   +3 more
doaj   +1 more source

Rhoifolin Alleviates Ulcerative Colitis by Targeting NMNAT1 and Activating SIRT1‐FOXO1 Signaling to Enhance ILC3s Effector Function

Advanced Science, EarlyView.
Rhoifolin directly targets NMNAT1, thereby activating nicotinamide salvage pathway and promoting intracellular NAD+ biosynthesis. Elevated NAD+ levels enhance SIRT1 activity, leading to FOXO1 deacetylation and nuclear translocation. Nuclear FOXO1 subsequently binds to the IL‐22 promoter, upregulating IL‐22 transcription and potentiating ILC3 effector ...
Hongqiong Yang, Yishu Zhang, Sijia Feng, Xiaoqing Ma, Jiayi Feng, Junwei Wang, Jialin Gao, An Pan, Dapeng Wu, Kang Ding, Caijuan Zheng, Qi Lv, Lihong Hu   +12 more
wiley   +1 more source

MICROSCOPIC TRAFFIC SIMULATION USING VANETS TRAFFIC SIMULATOR VISSIM

International Journal of Research in Engineering and Technology, 2014
The growth of motorization on highways in India has so far been of 2-wheeler and 3-wheeler variety, imposing negative impacts on both bus and car transport. It has also resulted in highly heterogeneous traffic conditions with varying static and dynamic characteristics of different types of vehicles.
openaire   +1 more source

Examining Driver Behavior in Response to Work Zone Interventions: A Driving Simulator Study, 2010 [PDF]

, 2010
Construction zones pose a significant threat to both workers and drivers causing numerous injuries and deaths each year. Innovations in work zone safety could reduce these numbers.

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