Results 181 to 190 of about 813,117 (289)

Unraveling A4GALT Mechanism and Its Modulation With Adamantyl‐Galactosylceramide Analogues: Advancing Fabry Disease Therapeutic Strategies

Angewandte Chemie, EarlyView.
A 310‐helix‐mediated conformational switch promotes a front‐face SNi‐like catalysis by human A4GALT. Mechanism‐guided design identifies AdaGalCer as a selective modulator of globotriaosylceramide (Gb3) biosynthesis, opening a clear route toward new Fabry disease therapeutics.
Nicky de Koster, Òscar Vidal‐Gironès, Rowan de Graaf, Ken Kok, Lindsey T. Lelieveld, Jackelien Hoogervorst, Maria J. Ferraz, José Pablo Rivas‐Fernández, Rob F. Lammers, Herman S. Overkleeft, Johannes M. F. G. Aerts, Rolf G. Boot, Carme Rovira, Marta Artola   +13 more
wiley   +2 more sources

Safe return to driving after severe acquired brain injury: toward a tiered multidisciplinary rehabilitation pathway. [PDF]

Front Neurol
Saviola D, Bruni S, Cantoni M, De Tanti A.   +3 more
europepmc   +1 more source

Artificial Intelligence and Access to Justice at the ‘Shop Front’: The Potential and Limitations of Meeting Legal Need Through Technology

Australian Journal of Social Issues, EarlyView.
ABSTRACT In Australia, governments fund Community Legal Centres (CLCs) as part of the legal assistance sector (LAS) to meet the ‘legal needs’ of people experiencing disadvantage who cannot afford private legal services. Persistent unmet demand for CLCs is well‐documented. As artificial intelligence (AI) is increasingly used in private legal practice to
Catherine Hastings, Art Cotterell, Farzana Bruce   +2 more
wiley   +1 more source

Datasets for distributed denial-of-service detection in healthcare internet of things environments. [PDF]

Data Brief
Akhi M, Eising C, Dhirani LL.
europepmc   +1 more source

The liver‐brain axis: A multidimensional regulatory network implicated in Alzheimer's disease pathogenesis and clinical implications

Animal Models and Experimental Medicine, EarlyView.
Schematic diagram of the core pathways of the liver‐brain axis in regulating AD. The liver regulates cerebral Aβ deposition, tau phosphorylation, and neuroinflammation through pathways such as metabolic detoxification (urea cycle, ketone body metabolism, glutathione antioxidant system), molecular secretion (APOE, CRP, FGF21, IGF‐1), and Aβ clearance ...
Ning Zhang, Wei Chen, Meng Wang
wiley   +1 more source

The Ecological Transformation of Successful Intelligence: How High-Stakes Professional Contexts Reshape the Functional Architecture of the Triarchic Model. [PDF]

J Intell
Yu Y, Wang Y, Xie L, Wu Y.
europepmc   +1 more source

Vehicle-Road Wear Microplastics: Fragmented Understanding of Their Impacts on Environment. [PDF]

Research (Wash D C)
Hai Y, Yang X, Luan S, Fan Z, He Y, Yang Q, Lu G, Wang C, Wang D, Alberto C.   +9 more
europepmc   +1 more source

Optimizing Urban Traffic Efficiency and Safety via V2X: A Simulation Study Using the MOSAIC Platform. [PDF]

Sensors (Basel)
Alupoaei SI, Caruntu CF.
europepmc   +1 more source

Security in Wireless Sensor Networks Using OMNET++: Literature Review. [PDF]

Sensors (Basel)
Shaik M, Kim SW.
europepmc   +1 more source

Technology-enhanced training in basic robotic surgical skills: a systematic review. [PDF]

J Robot Surg
Shakir T, Lingam G, Boal M, Francis N, Chand M.   +4 more
europepmc   +1 more source