Results 41 to 50 of about 745,871 (341)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Dual Weakly Supervised Anomaly Detection and Unsupervised Segmentation for Real-Time Railway Perimeter Intrusion Monitoring

Sensors
The high operational velocities of high-speed trains present constraints on their onboard track intrusion detection systems for real-time capture and analysis, encompassing limited computational resources and motion image blurring.
Donghua Wu, Yi Tian, Fangqing Gao, Xiukun Wei, Changfan Wang   +4 more
doaj   +1 more source

Modelling of Noise Pollution Due to Heterogeneous Highway Traffic in India

Transport and Telecommunication, 2019
Compared to homogeneous traffic flow, traffic speed variation is drastic with the involvement of heterogeneity. With an intent of studying the negative upshot of fluctuating speeds of heterogeneous traffic on the environment, the current paper is the ...
Kamineni Aditya, Duda Sunil Kumar, Chowdary Venkaiah, Prasad C.S.R.K.   +3 more
doaj   +1 more source

Automatic speed control of highway traffic [PDF]

, 1973
Vehicle control system monitors all vehicles in its range, and automatically slows down speeding vehicles by activating governor in vehicle. System determines only maximum speed; speeds below maximum are controlled by vehicle operator.
Klingman, E. E.
core   +1 more source

Criterion for traffic phases in single vehicle data and empirical test of a microscopic three-phase traffic theory

, 2005
A microscopic criterion for distinguishing synchronized flow and wide moving jam phases in single vehicle data measured at a single freeway location is presented.
Andreas Hiller, Banks J, Boris S Kerner, Bovy P H L, Fukui M Sugiyama Y Schreckenberg M Wolf D E, Gartner N H, Gurusinghe G S Nakatsuji T Azuta Y Ranjitkar P Tanaboriboon Y, Helbing D, Hoogendoorn S P Luding S Bovy P H L Schreckenberg M Wolf D E, Jiang R, Kerner B S, Kerner B S, Kerner B S, Kerner B S, Kerner B S Klenov S L Hiller A, Knospe W, Koshi M Iwasaki M Ohkura I Hurdle V F, Luttinen T, Mahmassani H S, Nagatani T, Sergey L Klenov, Tilch B Helbing D Helbing D Herrmann H J Schreckenberg M Wolf D E, Wagner P Fukui M Sugiyama Y Schreckenberg M Wolf D E, Wagner P Lubashevsky I   +23 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Simulating the Impact of Traffic Calming Strategies [PDF]

, 2019
This study assessed the impact of traffic calming measures to the speed, travel times and capacity of residential roadways. The study focused on two types of speed tables, speed humps and a raised crosswalk.
Chimba, Deo, Mbuya, Christian
core   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Quantification of Rear-End Crash Risk and Analysis of Its Influencing Factors Based on a New Surrogate Safety Measure

Journal of Advanced Transportation, 2021
Traditional surrogate measures of safety (SMoS) cannot fully consider the crash mechanism or fail to reflect the crash probability and crash severity at the same time.
Qiangqiang Shangguan, Ting Fu, Junhua Wang, Rui Jiang, Shou’en Fang   +4 more
doaj   +1 more source