Results 61 to 70 of about 116,487 (313)

Variations in urban traffic volumes

European Journal of Transport and Infrastructure Research, 2008
This paper describes the variation in traffic volumes in the Dutch city of Almelo. For this study, we used traffic counts which were collected at about 20 intersections from September 2004 until September 2005. The objective of this study is to provide insight in both periodic and random variation in urban traffic volumes.
Thomas, Tom, Weijermars, Wendy, van Berkum, Eric C.   +2 more
openaire   +3 more sources

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

FEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel, Sam Bennett, Natalie Ehlinger, Nelson Cook, Katelyn Marvin, Caleb L. Lines, Sam Reyes, Brooke Kirby, Shawn M. Ellerbroek   +8 more
wiley   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Use of Roadside Deer Removal to Reduce Deer–Vehicle Collisions

Human-Wildlife Interactions, 2020
Identification of management tools to reduce the incidence of deer–vehicle collisions (DVCs) is important to improve motorist safety. Sharpshooting to reduce white-tailed deer (Odocoileus virginianus; deer) along roads has proven successful in urban ...
John C. Kilgo, Thomas Mims, John I. Blake, Tracy E. Grazia, Andy Horcher, Michael Larsen, Stanley J. Zarnoch   +6 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Traffic Flow Characteristics with Transportation Plans Components

, 2012
Knowledge of traffic characteristics is useful to the highwayengineer in developing highway and transportation plans, performingeconomic analyses, establishing geometric design criteria,selecting and implementing traffic control measures, andevaluating ...
Hrvoje Baričević, Čedomir Dundović
core   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Refining the ambulance travel model for more accurate transport time estimation

Nihon Kikai Gakkai ronbunshu
This paper refines the ambulance travel model, which is used to determine the optimal route from an emergency site to a hospital, to enhance the accuracy of travel time estimation.
Takahiko ONO, Hikaru HIGAKI
doaj   +1 more source

Toward the Theory of Traffic Flow Organisation

, 2002
Every traffic network can be reorganised, i.e. the trafficflows may be redirected and guided along other routes. Mathematicalcalculation of the number of intersecting points, mergingand diverging of traffic can determine the cu"ent volume ofconflicting ...
Goran Kos, Emil Gašparić, Ivan Dadić
core   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source