Results 41 to 50 of about 8,780,830 (305)
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Right-Turn Traffic Volume Adjustment in Traffic Signal Warrant Analysis [PDF]
Transportation Research Record: Journal of the Transportation Research Board, 2016 An intersection with heavy right-turn volumes, without any reduction, might mislead a signal warrant analysis, and a different conclusion may be reached on whether a signal is warranted. Previous right-turn volume reduction methods based mostly on engineering judgment lack specific theoretical backgrounds.
Zhou, C, Tian, Z
openaire +1 more source
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
International Journal of Transportation Science and TechnologyWith the rapid expansion of urban areas, intercity highways have become crucial for daily transportation. Traffic administrators and planners increasingly rely on evaluating highway traffic volume.
Peiqun Lin +3 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Adaptive random sampling for traffic volume measurement [PDF]
Telecommunication Systems, 2006 Traffic measurement and monitoring are an important component of network management and traffic engineering. With high-speed Internet backbone links, efficient and effective packet sampling techniques for traffic measurement and monitoring are not only desirable, but also increasingly becoming a necessity.
Baek-Young Choi, Zhi-Li Zhang
openaire +3 more sources
Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens
FEBS Open Bio, EarlyView.Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee +3 more
wiley +1 more source
MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis
FEBS Open Bio, EarlyView.MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss +7 more
wiley +1 more source
Traffic control signal design manual
, 2009 Title from PDF cover (DOT web site, viewed Dec. 3, 2009).; Previously published: Manual of traffic control signal design. [Wethersfield, Conn] : Dept. of Transportation, Bureau of Highways, Office of Engineering, Division of Traffic, [1984].; Includes ...
core +1 more source