Results 201 to 210 of about 968,579 (338)

Design and Dynamic Locomotion Control of Quadruped Robot with Perception-Less Terrain Adaptation. [PDF]

Cyborg Bionic Syst, 2022
Wang L, Meng L, Kang R, Liu B, Gu S, Zhang Z, Meng F, Ming A.   +7 more
europepmc   +1 more source

Targeting the PGRN‐BMP Lysosomal Axis With NPs@PGRN Reverses Immunometabolic Dysfunction in Chronic Septic Arthritis

Advanced Science, EarlyView.
Chronic septic arthritis involves intracellular bacterial persistence and lipid‐immune crosstalk via the PGRN‐BMP lysosomal axis. A dual‐targeting nanoparticle system (NPs@PGRN) restores lysosomal bactericidal function, reduces bacterial burden, and reprograms macrophage immunity, offering a novel therapeutic strategy. ABSTRACT Chronic septic arthritis,
Congsun Li, Jiaqi Fan, Tao Sun, Wushi Cui, Jiaxuan Zou, Weinan Yang, Liang Chen, Jian Xiao, Shicheng Wang, Tao Zhang, Jianqiao Hong, An Liu, Haobo Wu   +12 more
wiley   +1 more source

Ultrasoft hydrogel immune millirobot with multimodal locomotion. [PDF]

Sci Adv
Zheng Z, Demir SO, Wu A, Zhong S, Xin Z, Yuan C, Wang H, Sitti M, Sun Y, Dong L.   +9 more
europepmc   +1 more source

Periodic Bedrock Ridges at the ExoMars 2022 Landing Site: Evidence for a Changing Wind Regime. [PDF]

Geophys Res Lett, 2021
Silvestro S, Pacifici A, Salese F, Vaz DA, Neesemann A, Tirsch D, Popa CI, Pajola M, Franzese G, Mongelluzzo G, Ruggeri AC, Cozzolino F, Porto C, Esposito F.   +13 more
europepmc   +1 more source

Endocytic Control of Cell‐Autonomous and Non‐Cell‐Autonomous Functions of p53

Advanced Science, EarlyView.
NUMB Ex3‐containing isoforms localize to the plasma membrane, where they recruit p53 through SNX9 and direct it to multivesicular bodies and exosomes. Exported p53 is taken up by neighboring cells and activates nuclear programs, revealing an intercellular, exosome‐based pathway that might help establish a tumor‐suppressive microenvironment.
Roberta Cacciatore, Andrea Basile, Stefano Freddi, Irene Schiano Lomoriello, Carlo Ribelle Zucca, Giuseppe Ciossani, Luigi Scietti, Alessandro Cuomo, Simona Ronzoni, Simone Pelicci, Mario Faretta, Elena Zaccheroni, Giuliana Pelicci, Vittoria Matafora, Angela Bachi, Rosalind Helen Gunby, Salvatore Pece, Sara Sigismund, Letizia Lanzetti, Ivan Nicola Colaluca, Pier Paolo Di Fiore   +20 more
wiley   +1 more source

Discrete element method (DEM) and soil bin evaluation of farmyard manure and tire traffic on the soil compaction. [PDF]

Sci Rep
Dehghan S, Shahgholi G, Sharabiani VR, Moinfar A, Szymanek M, Dziwulska-Hunek A.   +5 more
europepmc   +1 more source

NPM1 Mediates mRNA Sorting into Extracellular Vesicles via Specific RNA Motif Binding and Phase Separation

Advanced Science, EarlyView.
NPM1 selectively sorts specific mRNAs into extracellular vesicles (EVs) by recognizing RNA motifs and forming phase‐separated condensates. These mRNA cargos—including EGFR—are then loaded via multivesicular bodies. This active sorting pathway, validated in EVs derived from both lung cancer cells and patient serum, reveals a specific mechanism for ...
Kaixiang Zhang, Gaoge Sun, Xiangzheng Liu, Shuai Zuo, Pengyuan Wang, Boxiao Zhan, Zhi John Lu, Hang Yin, Ying Zhang   +8 more
wiley   +1 more source

Insufficient Logging Intervals Impede Upper Soil Recovery in Temperate Beech Forests: Insights From Two Case-Studies in Poland. [PDF]

Ecol Evol
Latterini F, Horodecki P, Dyderski MK, Kamczyc J, Witkowski R, Venanzi R, Jagodziński AM.   +6 more
europepmc   +1 more source

Timing Mechanotransduction: Mechanically Dynamic Biomaterials Reveal the Temporal Hierarchy of YAP/TAZ Control Nodes

Advanced Science, EarlyView.
This work develops dynamically softening polyacrylamide hydrogels for time‐resolved imaging during continuous mechanical transitions. The study revealed that mechanotransduction is biphasic; YAP/TAZ inactivation is driven by early loss of the nucleocytoskeletal continuum connecting subnuclear adhesions, F‐actin, and the nuclear envelope, coupled with ...
Alessandro Gandin, Giada Vanni, Veronica Torresan, Margherita Pelosin, Rebecca Busetto, Anna Citron, Ambela Suli, Paolo Contessotto, Carlo Albanese, Francesca Zanconato, Tito Panciera, Stefano Piccolo, Giovanna Brusatin   +12 more
wiley   +1 more source

Stability and trajectory tracking of four- wheel steering trackless auxiliary transport robot via PID control. [PDF]

Front Robot AI
Hao M, Bi Y, Ren J, Ma L, Li J, Zhao S, Wu M.   +6 more
europepmc   +1 more source