Results 131 to 140 of about 274,726 (298)

DMAP1 Deficiency Suppresses Lung Cancer Progression by Destabilizing Replication Fork and Activating IFN Signaling‐Mediated Anti‐tumor Immunity

open access: yesAdvanced Science, EarlyView.
Lung cancer remains the leading cause of cancer‐related death. We investigated the role of the epigenetic regulator DMAP1 in NSCLC and found that its loss induces replication stress and DNA damage. This in turn activates type I IFN signaling via the cGAS–STING pathway and transcriptional ISG de‐repression, enhancing anti‐tumor immune responses ...
Kan Huang   +10 more
wiley   +1 more source

Transnational Karbala: From Rebellion to Reconciliation

open access: yesReligions
This article for the first time examines the activities of transnational information campaigns initiated by young Shiʿa Muslims across European, Russian, and Armenian cities. These campaigns aim to disseminate knowledge about Imam Hussain and his mission
Minoo Mirshahvalad
doaj   +1 more source

Tragedy of the Regulatory Commons: LightSquared and the Missing Spectrum Rights [PDF]

open access: yes, 2014
The endemic underuse of radio spectrum constitutes a tragedy of the regulatory commons. Like other common interest tragedies, the outcome results from a legal or market structure that prevents economic actors from executing socially efficient bargains ...
Hazlett, Thomas W., Skorup, Brent
core   +1 more source

Microscale Mapping of Fiber Strain and Damage in Composite Wrinkled Laminates Using Computed Tomography Assisted Wide‐Angle X‐Ray Scattering

open access: yesAdvanced Science, EarlyView.
This study combines full‐field tomography with diffraction mapping to quantify radial (ε002$\varepsilon _{002}$) and axial (ε100$\varepsilon _{100}$) lattice strain in wrinkled carbon‐fiber specimens for the first time. Radial microstrain gradients (−14.5 µεMPa$\varepsilon \mathrm{MPa}$−1) are found to signal damage‐prone zones ahead of failure, which ...
Hoang Minh Luong   +7 more
wiley   +1 more source

Dual‐Targeting Cuproptosis and Mitophagy via a Flavopiridol‐Copper Nanoplatform Potentiates Immunotherapy Against Uveal Melanoma

open access: yesAdvanced Science, EarlyView.
This study develops a GSH‐responsive nanoplatform, NP@Fla‐Cu, to co‐activate cuproptosis and excessive mitophagy in uveal melanoma. The nanoplatform enhances tumor‐specific copper delivery, depletes antioxidant defenses, and remodels the tumor immune microenvironment.
Hong Ren   +5 more
wiley   +1 more source

Memory as Part of an Event, and Events as Signification of Memories: Focusing on Philippe Claudel’s Brodeck’s Report

open access: yesReligions
This paper attempts to reconceptualize memory as an event from a theological perspective, drawing on the recent dialog between memory studies and Critical Event Studies. To this end, it analyzes the narrative and themes of the 2007 novel Brodeck’s Report
Yongtaek Jeong
doaj   +1 more source

In Vivo CRISPR Screening Identifies the Glutamate Receptor GRIA2 as Promoting Peritoneal Metastasis of Gastric Cancer via Calcium‐Dependent β‐Catenin Activation

open access: yesAdvanced Science, EarlyView.
We identified GRIA2 as a critical driver of gastric cancer peritoneal metastasis through in vivo CRISPR screening. Mechanistically, GRIA2‐mediated calcium influx inhibits GSK3β and activates Wnt/β‐catenin signaling, driven by glutamate from cancer‐associated fibroblasts.
Jie Sun   +13 more
wiley   +1 more source

Carnefice o spettatore? L’ingaggio spettatoriale in The Repetition. Histoire(s) du théâtre di Milo Rau

open access: yesAnnali Online dell'Università di Ferrara. Sezione Lettere, 2019
Starting from the idea that every single work of art is perceived through not only our senses but also our mind, and that the theatrical event is a privileged occasion during which the cognitive world is connected with the emotional dimension of the ...
Ester Fuoco
doaj   +1 more source

Ultrastrong TEMPO‐Oxidized Densified Bamboo via Interface Decoupling and Hierarchical Toughening

open access: yesAdvanced Science, EarlyView.
This study develops TEMPO‐oxidized densified bamboo that achieves ultrahigh strength and toughness by decoupling rigid hydrogen bonds into reversible van der Waals interactions. TEMPO oxidation reorganizes the cellulose hydrogen‐bonding network, facilitating energy dissipation via reversible interactions, thereby establishing a general strategy to ...
Ziyu Ba   +5 more
wiley   +1 more source

Andrzej Wajda’s Hamlet (IV) - a Metatheatrical Reading of Hamlet [PDF]

open access: yes, 2003
Zadanie pt. „Digitalizacja i udostępnienie w Cyfrowym Repozytorium Uniwersytetu Łódzkiego kolekcji czasopism naukowych wydawanych przez Uniwersytet Łódzki” nr 885/P-DUN/2014 dofinansowane zostało ze środków MNiSW w ramach działalności upowszechniającej ...
Czyżykowska, Katarzyna
core  

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