Results 51 to 60 of about 307,180 (268)

On the campaign trail [PDF]

BMJ, 1983
One of the aspects of a general election campaign that the voters never see is the way that a party leader's speech grows and grows in performance. The point is that the actual audience at each rally hears basically the same speech, but with sections added to highlight the issue of the day.
openaire   +2 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Differential white blood cell count and epigenetic clocks: a bidirectional Mendelian randomization study

Clinical Epigenetics
Background Human aging and white blood cell (WBC) count are complex traits influenced by multiple genetic factors. Predictors of chronological age have been developed using epigenetic clocks.
Manli Sun, Huan Yang, Yang Hu, Jiaqi Fan, Mingjing Duan, Jingqi Ruan, Shichang Li, Yang Xu, Yue Han   +8 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Pedological aspects as environmental quality indicators of a touristic trail in the Serra do Cipó National Park/MG

REM: International Engineering Journal
Soil provides important support for anthropogenic activities, and earthen trails, which have always been present in the natural landscape, are routes of access to various tourist attractions. In recent decades, trails have been widely used as a method of
Ricardo Eustáquio Fonseca Filho, Angélica Fortes Drummond Chicarino Varajão, Múcio do Amaral Figueiredo, Paulo de Tarso Amorim Castro   +3 more
doaj   +1 more source

La promoción del turismo rural a través del "trail running": el caso de Carrícola en la comarca de "La Vall d'Albaida"

PASOS Revista de Turismo y Patrimonio Cultural, 2017
El running se ha convertido en poco tiempo en un deporte de masas, generando todo un negocio a su alrededor y un impacto económico importante en aquellas localidades que albergan este tipo de eventos.
FEDERICO SOLER VAYÁ, ENRIQUE SAN MARTÍN GONZÁLEZ   +1 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

The information trail

eLife, 2016
The ability of a wild baboon to acquire and exploit social information depends on its individual characteristics and its position within various social networks.
openaire   +3 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Feeding trails of Dugong Dugong dugon (Müller, 1776) (Mammalia: Sirenia: Dugongidae) in the Gulf of Kachchh, western coast of India

Journal of Threatened Taxa, 2019
Dugong Dugong dugon (Müller, 1776) is the only herbivorous marine mammal distributed along the tropical and subtropical oceans of the Indo-Pacific regions.
Deepak Apte, Dishannt Parasharya, Bhavik Patel   +2 more
doaj   +1 more source