Targeting TRAIL Death Receptors in Triple-Negative Breast Cancers: Challenges and Strategies for Cancer Therapy. [PDF]
Cells, 2022 The tumor necrosis factor (TNF) superfamily member TNF-related apoptosis-inducing ligand (TRAIL) induces apoptosis in cancer cells via death receptor (DR) activation with little toxicity to normal cells or tissues.
Kundu M, Greer YE, Dine JL, Lipkowitz S.
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Salinomycin inhibits epigenetic modulator EZH2 to enhance death receptors in colon cancer stem cells. [PDF]
Epigenetics, 2021 Drug resistance is one of the trademark features of Cancer Stem Cells (CSCs). We and others have recently shown that paucity of functional death receptors (DR4/5) on the cell surface of tumour cells is one of the major reasons for drug resistance, but ...
Singh AK +11 more
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Tristetraprolin Posttranscriptionally Downregulates TRAIL Death Receptors. [PDF]
Cells, 2020 Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) has attracted attention as a potential candidate for cancer therapy. However, many primary cancers are resistant to TRAIL, even when combined with standard chemotherapy.
Lee WH +8 more
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Death Receptors DR4 and DR5 Undergo Spontaneous and Ligand-Mediated Endocytosis and Recycling Regardless of the Sensitivity of Cancer Cells to TRAIL. [PDF]
Front Cell Dev Biol, 2021 Tumor necrosis factor-associated ligand inducing apoptosis (TRAIL) induces apoptosis through the death receptors (DRs) 4 and 5 expressed on the cell surface. Upon ligand stimulation, death receptors are rapidly internalized through clathrin-dependent and
Artykov AA +5 more
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The Association of Death Receptors and TGF-β1 Expression in Urothelial Bladder Cancer and Their Prognostic Significance. [PDF]
BiomedicinesDeath receptor signalization that triggers the extrinsic apoptotic pathway and TGF-β1 have important roles in urothelial carcinogenesis, with a complex interplay between them. The aim of this research was to assess the association of death receptors DR4,
Stojnev S +6 more
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TRAIL and curcumin codelivery nanoparticles enhance TRAIL-induced apoptosis through upregulation of death receptors. [PDF]
Drug Deliv, 2017 Active targeting nanoparticles were developed to simultaneously codeliver tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and Curcumin (Cur).
Yang X +5 more
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Platelet Apoptosis Can Be Triggered Bypassing the Death Receptors. [PDF]
Clin Appl Thromb Hemost, 2019 In nucleated cells, the extrinsic pathway of the programmed cell death (apoptosis) is triggered by interaction of death ligands of the tumor necrosis factor superfamily with the death receptors on external cell surface membrane.
Leytin V, Gyulkhandanyan AV, Freedman J.
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Editorial: Death Receptors, Non-apoptotic Signaling Pathways and Inflammation. [PDF]
Front Immunol, 2020 Szegezdi E, Legembre P.
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Bi-specific molecule against EGFR and death receptors simultaneously targets proliferation and death pathways in tumors. [PDF]
Sci Rep, 2017 Developing therapeutics that target multiple receptor signaling pathways in tumors is critical as therapies targeting single specific biomarker/pathway have shown limited efficacy in patients with cancer.
Zhu Y +7 more
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Frontiers in Immunology, 2023 BackgroundTNF-related apoptosis-inducing ligand (TRAIL) is a member of the TNF superfamily that can either induce cell death or activate survival pathways after binding to death receptors (DRs) DR4 or DR5.
Sinem Gunalp +15 more
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