Results 41 to 50 of about 608,414 (287)

BAK-up: the receptor kinase BAK-TO-LIFE 2 enhances immunity when BAK1 is lacking

Stress Biology, 2023
BRI1-ASSOCIATED KINASE 1 (BAK1/SERK3) and its closest homolog BAK1-LIKE 1 (BKK1/SERK4) are leucine-rich repeat receptor kinases (LRR-RKs) belonging to the SOMATIC EMBRYOGENESIS RECEPTOR KINASE (SERK) family.
Vahid Fallahzadeh-Mamaghami, Hannah Weber, Birgit Kemmerling   +2 more
doaj   +1 more source

Differential activation of JNK1 isoforms by TRAIL receptors modulate apoptosis of colon cancer cell lines

, 2009
Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) induces apoptosis on binding to its receptors, death receptor 4 and 5 (DR4, DR5).
M Keane, Mehmet, H, A Samali, D Mahalingam, H Mehmet, Mahalingam, D, E Szegezdi, Szegezdi, E, Keane, M, G Pirianov, Pirianov, G, Samali, A   +11 more
core   +1 more source

Combination of TRAIL with bortezomib shifted apoptotic signaling from DR4 to DR5 death receptor by selective internalization and degradation of DR4. [PDF]

PLoS ONE, 2014
TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) mediates apoptosis in cancer cells through death receptors DR4 and DR5 preferring often one receptor over another in the cells expressing both receptors.
Maxim L Bychkov, Marine E Gasparian, Dmitry A Dolgikh, Mikhail P Kirpichnikov   +3 more
doaj   +1 more source

Fetal-derived trophoblast use the apoptotic cytokine tumor necrosis factor-alpha-related apoptosis-inducing ligand to induce smooth muscle cell death.

, 2007
Remodeling of the uterine spiral arteries during pregnancy transforms them from high to low resistance vessels that lack vasoconstrictive properties. This process is essential to meet the demand for increased blood flow imposed by the growing fetus. Loss
Cartwright, JE, Aplin, JD, Whitley, GS, Keogh, RJ, Freeman, A, Harris, LK, Baker, PN   +6 more
core   +1 more source

Cancer Cell Growth Inhibitory Effect of Bee Venom via Increase of Death Receptor 3 Expression and Inactivation of NF-kappa B in NSCLC Cells

Toxins, 2014
Our previous findings have demonstrated that bee venom (BV) has anti-cancer activity in several cancer cells. However, the effects of BV on lung cancer cell growth have not been reported.
Kyung Eun Choi, Chul Ju Hwang, Sun Mi Gu, Mi Hee Park, Joo Hwan Kim, Joo Ho Park, Young Jin Ahn, Ji Young Kim, Min Jong Song, Ho Sueb Song, Sang-Bae Han, Jin Tae Hong   +11 more
doaj   +1 more source

A self-sustaining nanoplatform overcomes TRAIL-resistance of pancreatic cancer by a source-broadening and expenditure-reducing apoptosis strategy

Materials & Design, 2021
Pancreatic cancer generates resistance to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) by downregulating death receptors and switching pro-apoptosis to anti-apoptosis through caspases blockers like X-linked inhibitor of apoptosis ...
Xianzhou Huang, Haijun Li, Chunqing Ou, Yaqian Shu, Rui Luo, Xinchao Li, Shouchun Chen, Qinjie Wu, Changyang Gong, Lei Liu   +9 more
doaj   +1 more source

Filoviruses: Innate Immunity, Inflammatory Cell Death, and Cytokines

Pathogens, 2022
Filoviruses are a group of single-stranded negative sense RNA viruses. The most well-known filoviruses that affect humans are ebolaviruses and marburgviruses. During infection, they can cause life-threatening symptoms such as inflammation, tissue damage,
Jianlin Lu, Jessica M. Gullett, Thirumala-Devi Kanneganti   +2 more
doaj   +1 more source

Death Receptors: New Opportunities in Cancer Therapy. [PDF]

Acta Naturae, 2017
© 2017 Park-media, Ltd. This article offers a detailed review of the current approaches to anticancer therapy that target the death receptors of malignant cells.
Ukrainskaya VM, Stepanov AV, Glagoleva IS, Knorre VD, Belogurov AAJ, Gabibov AG.   +5 more
europepmc   +3 more sources

A Bibliometric Analysis of Publications in Uremic Toxins From 1991 to 2024

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Uremic toxins are a growing area of research in nephrology, with significant implications in the progression and treatment of chronic kidney disease (CKD) and the management of end‐stage kidney disease (ESKD). This bibliometric analysis aims to evaluate the global research trends, key contributors, and the impact of publications in ...
Yuh‐Shan Ho, Karim M. Soliman, Wisit Cheungpasitporn, Wannasit Wathanavasin, Ahmed Daoud, Ahmed I. Kamal, Balázs Szamosfalvi, Tibor Fülöp   +7 more
wiley   +1 more source

Death Receptor-Mediated Cell Death and Proinflammatory Signaling in Nonalcoholic SteatohepatitisSummary

Cellular and Molecular Gastroenterology and Hepatology, 2015
Nonalcoholic fatty liver disease (NAFLD) is becoming a public health problem worldwide. A subset of patients develop an inflammatory disease, nonalcoholic steatohepatitis (NASH), characterized by steatosis, hepatocellular death, macrophage and neutrophil
Petra Hirsova, Gregory J. Gores
doaj   +1 more source