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Filoviruses: Innate Immunity, Inflammatory Cell Death, and Cytokines
Pathogens, 2022 Filoviruses are a group of single-stranded negative sense RNA viruses. The most well-known filoviruses that affect humans are ebolaviruses and marburgviruses. During infection, they can cause life-threatening symptoms such as inflammation, tissue damage,
Jianlin Lu +2 more
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Cellular and Molecular Gastroenterology and Hepatology, 2015 Nonalcoholic fatty liver disease (NAFLD) is becoming a public health problem worldwide. A subset of patients develop an inflammatory disease, nonalcoholic steatohepatitis (NASH), characterized by steatosis, hepatocellular death, macrophage and neutrophil
Petra Hirsova, Gregory J. Gores
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Frontiers in Cell and Developmental Biology, 2019 Innate immune signaling and programmed cell death are intimately linked, and many signaling pathways can regulate and induce both, transcription of inflammatory mediators or autonomous cell death.
Valentin J. Heim +4 more
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A novel motif identified in dependence receptors. [PDF]
PLoS ONE, 2007 Programmed cell death signaling is a critical feature of development, cellular turnover, oncogenesis, and neurodegeneration, among other processes.
Gabriel del Rio +3 more
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Potential Role of Tarantula Venom Peptides in Targeting Human Death Receptors: A Computational Study
Applied SciencesAnimal venom has been gaining traction as a potential source of therapeutics for various diseases. Spiders encompass a wide variety of venom-producing species, of which tarantulas of the family Theraphosidae are widely known across the globe.
Janus Isaiah R. Quiambao +2 more
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AMPA receptors are the major mediators of excitotoxic death in mature oligodendrocytes
Neurobiology of Disease, 2003 Myelination of axons is important for central nervous system function, but oligodendrocytes, which constitute CNS myelin, are vulnerable to excitotoxic injury and death.
Elizabeth A Leuchtmann +4 more
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M1 muscarinic receptor activation mediates cell death in M1-HEK293 cells. [PDF]
PLoS ONE, 2013 HEK293 cells have been used extensively to generate stable cell lines to study G protein-coupled receptors, such as muscarinic acetylcholine receptors (mAChRs).
E Scott Graham +6 more
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P2X7 receptor: Death or life? [PDF]
Purinergic Signalling, 2005 The P2X(7) plasma membrane receptor is an intriguing molecule that is endowed with the ability to kill cells, as well as to activate many responses and even stimulate proliferation. Here, the authors give an overview on the multiplicity and complexity of P2X(7)-mediated responses, discussing recent information on this receptor. Particular attention has
ADINOLFI, Elena +6 more
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Regulation of anoikis by extrinsic death receptor pathways
Cell Communication and Signaling, 2023 Metastatic cancer cells can develop anoikis resistance in the absence of substrate attachment and survive to fight tumors. Anoikis is mediated by endogenous mitochondria-dependent and exogenous death receptor pathways, and studies have shown that caspase-
Ying-Hao Han +5 more
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Frontiers in Cellular Neuroscience, 2016 Cytoplasmic Ca2+ actively engages in diverse intracellular processes from protein synthesis, folding and trafficking to cell survival and death. Dysregulation of intracellular Ca2+ levels is observed in various neuropathological states including ...
Kyung Min eChung +4 more
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