Results 21 to 30 of about 603,056 (111)

PD-L1 expression is regulated by both DNA methylation and NF-kB during EMT signaling in non-small cell lung carcinoma

OncoImmunology, 2018
Tumor cells, which undergo Epithelial-mesenchymal transition (EMT) acquire increased capacities of proliferation, invasion and have the ability to generate metastases by escaping the immune system during their systemic migration.
A. Asgarova, K. Asgarov, Y. Godet, P. Peixoto, A. Nadaradjane, M. Boyer-Guittaut, J. Galaine, D. Guenat, V. Mougey, J. Perrard, J. R. Pallandre, A. Bouard, J. Balland, C. Tirole, O. Adotevi, E. Hendrick, M. Herfs, P. F. Cartron, C. Borg, E. Hervouet   +19 more
doaj   +1 more source

Induction Apoptosis of Erinacine A in Human Colorectal Cancer Cells Involving the Expression of TNFR, Fas, and Fas Ligand via the JNK/p300/p50 Signaling Pathway With Histone Acetylation

Frontiers in Pharmacology, 2019
Erinacine A, which is one of the major bioactive diterpenoid compounds extracted from cultured mycelia of H. erinaceus, displays great antitumorigenic activity.
Ko-Chao Lee, Ko-Chao Lee, Kam-Fai Lee, Shui-Yi Tung, Shui-Yi Tung, Wen-Shih Huang, Wen-Shih Huang, Li-Ya Lee, Wan-Ping Chen, Chin-Chu Chen, Chih-Chuan Teng, Chih-Chuan Teng, Chien-Heng Shen, Chien-Heng Shen, Meng-Chiao Hsieh, Meng-Chiao Hsieh, Hsing-Chun Kuo, Hsing-Chun Kuo, Hsing-Chun Kuo, Hsing-Chun Kuo   +19 more
doaj   +1 more source

A DR4, DR5 Targeting Conjugated TRAIL Treatment for Colorectal Carcinogenesis: A Way to Future? [PDF]

Pharmaceutical Sciences
TRAIL or tumor necrosis factor-related apoptosis-inducing ligand has been one of the major frontiers for the chemotherapeutic approach to treating carcinogenesis.
Parikshit Roychowdhury, Indhumathi Thirugnanasambandham, Anindita De, Mirunalini Gobinath, Samanwita Khanra, Veera Venkata Satyanarayana Reddy Karri, Nihar Ranjan Bhuyan, Gowthamrajan Kuppusamy   +7 more
doaj   +1 more source

Theaflavin-3,3′-Digallate Suppresses Human Ovarian Carcinoma OVCAR-3 Cells by Regulating the Checkpoint Kinase 2 and p27 kip1 Pathways

Molecules, 2019
Theaflavin-3,3′-digallate (TF3) is a unique polyphenol in black tea. Epidemiological studies have proved that black tea consumption decreases the incidence rate of ovarian cancer.
Ying Gao, Junfeng Yin, Youying Tu, Yi Charlie Chen   +3 more
doaj   +1 more source

Role of Glycans on Key Cell Surface Receptors That Regulate Cell Proliferation and Cell Death

Cells, 2021
Cells undergo proliferation and apoptosis, migration and differentiation via a number of cell surface receptors, most of which are heavily glycosylated.
Yin Gao, Xue Luan, Jacob Melamed, Inka Brockhausen   +3 more
doaj   +1 more source

BAK-up: the receptor kinase BAK-TO-LIFE 2 enhances immunity when BAK1 is lacking

Stress Biology, 2023
BRI1-ASSOCIATED KINASE 1 (BAK1/SERK3) and its closest homolog BAK1-LIKE 1 (BKK1/SERK4) are leucine-rich repeat receptor kinases (LRR-RKs) belonging to the SOMATIC EMBRYOGENESIS RECEPTOR KINASE (SERK) family.
Vahid Fallahzadeh-Mamaghami, Hannah Weber, Birgit Kemmerling   +2 more
doaj   +1 more source

Combination of TRAIL with bortezomib shifted apoptotic signaling from DR4 to DR5 death receptor by selective internalization and degradation of DR4. [PDF]

PLoS ONE, 2014
TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) mediates apoptosis in cancer cells through death receptors DR4 and DR5 preferring often one receptor over another in the cells expressing both receptors.
Maxim L Bychkov, Marine E Gasparian, Dmitry A Dolgikh, Mikhail P Kirpichnikov   +3 more
doaj   +1 more source

Cancer Cell Growth Inhibitory Effect of Bee Venom via Increase of Death Receptor 3 Expression and Inactivation of NF-kappa B in NSCLC Cells

Toxins, 2014
Our previous findings have demonstrated that bee venom (BV) has anti-cancer activity in several cancer cells. However, the effects of BV on lung cancer cell growth have not been reported.
Kyung Eun Choi, Chul Ju Hwang, Sun Mi Gu, Mi Hee Park, Joo Hwan Kim, Joo Ho Park, Young Jin Ahn, Ji Young Kim, Min Jong Song, Ho Sueb Song, Sang-Bae Han, Jin Tae Hong   +11 more
doaj   +1 more source

A self-sustaining nanoplatform overcomes TRAIL-resistance of pancreatic cancer by a source-broadening and expenditure-reducing apoptosis strategy

Materials & Design, 2021
Pancreatic cancer generates resistance to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) by downregulating death receptors and switching pro-apoptosis to anti-apoptosis through caspases blockers like X-linked inhibitor of apoptosis ...
Xianzhou Huang, Haijun Li, Chunqing Ou, Yaqian Shu, Rui Luo, Xinchao Li, Shouchun Chen, Qinjie Wu, Changyang Gong, Lei Liu   +9 more
doaj   +1 more source

Filoviruses: Innate Immunity, Inflammatory Cell Death, and Cytokines

Pathogens, 2022
Filoviruses are a group of single-stranded negative sense RNA viruses. The most well-known filoviruses that affect humans are ebolaviruses and marburgviruses. During infection, they can cause life-threatening symptoms such as inflammation, tissue damage,
Jianlin Lu, Jessica M. Gullett, Thirumala-Devi Kanneganti   +2 more
doaj   +1 more source