Results 11 to 20 of about 608,414 (287)
Apoptosis: Silencing the death receptors [PDF]
Current Biology, 1999 Spontaneous signaling from death-domain-containing receptors can result in inappropriate cell death. An inhibitory protein has recently been identified, called silencer of death domains (SODD), that binds to the death domain of tumor necrosis factor receptor 1, thereby negatively regulating downstream signaling.
Tschopp J, Martinon F, Hofmann K
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Apoptosis signaling by death receptors
European Journal of Biochemistry, 1998 Death receptors have been recently identified as a subgroup of the TNF‐receptor superfamily with a predominant function in induction of apoptosis. The receptors are characterized by an intracellular region, called the death domain, which is required for the transmission of the cytotoxic signal.
Schulze-Osthoff, Klaus +4 more
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Bi-specific molecule against EGFR and death receptors simultaneously targets proliferation and death pathways in tumors [PDF]
Scientific Reports, 2017 Developing therapeutics that target multiple receptor signaling pathways in tumors is critical as therapies targeting single specific biomarker/pathway have shown limited efficacy in patients with cancer.
Yanni Zhu +7 more
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Frontiers in Immunology, 2023 BackgroundTNF-related apoptosis-inducing ligand (TRAIL) is a member of the TNF superfamily that can either induce cell death or activate survival pathways after binding to death receptors (DRs) DR4 or DR5.
Sinem Gunalp +15 more
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Pharmaceutics, 2023 The TRAIL (TNF-related apoptosis-inducing ligand) apoptotic pathway is extensively exploited in the development of targeted antitumor therapy due to TRAIL specificity towards its cognate receptors, namely death receptors DR4 and DR5.
Anne V. Yagolovich +2 more
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TRAIL and its receptors in cardiac diseases
Frontiers in Physiology, 2023 Cardiovascular disease is a leading cause of death worldwide. Loss of cardiomyocytes that occurs during many types of damage to the heart such as ischemic injury and stress caused by pressure overload, diminishes cardiac function due to their limited ...
Laurel A. Grisanti
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AIDS and the death receptors [PDF]
British Medical Bulletin, 1997 Activation-induced cell death (AICD) of T cells involves the CD95 receptor/ligand system. T cell activation through the T cell receptor results in expression of the CD95 ligand (CD95L) that acts on CD95+ cells by direct binding and in a paracrine or autocrine fashion.
M E, Peter +3 more
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Death receptor signaling [PDF]
Journal of Cell Science, 2005 Apoptosis or programmed cell death is a common property of multicellular organisms ([Danial and Korsmeyer, 2004][1]; [Krammer, 2000][2]). It can be triggered by a number of factors, including UV- or γ-irradiation, chemotherapeutic drugs or signaling by death receptors (DR).
Inna, Lavrik +2 more
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Genistein Sensitizes Human Cholangiocarcinoma Cell Lines to Be Susceptible to Natural Killer Cells
Biology, 2022 Cholangiocarcinoma (CCA) is a lethal bile duct cancer, which has poor treatment outcomes due to its high resistance to chemotherapy and cancer recurrence.
Chutipa Chiawpanit +4 more
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microRNAs and death receptors [PDF]
Cytokine & Growth Factor Reviews, 2008 Death receptors induce apoptosis through either the Type I or II pathway. In Type I cells, the initiator caspase-8 directly activates effector caspases such as caspase-3, whereas in Type II cells, the death signal is amplified through mitochondria thereby activating effector caspases causing cell death. Recently, there have been advances in elucidating
Sun-Mi, Park, Marcus E, Peter
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