Results 11 to 20 of about 603,056 (111)
Pharmaceutics, 2023 The TRAIL (TNF-related apoptosis-inducing ligand) apoptotic pathway is extensively exploited in the development of targeted antitumor therapy due to TRAIL specificity towards its cognate receptors, namely death receptors DR4 and DR5.
Anne V. Yagolovich +2 more
doaj +1 more source
TRAIL and its receptors in cardiac diseases
Frontiers in Physiology, 2023 Cardiovascular disease is a leading cause of death worldwide. Loss of cardiomyocytes that occurs during many types of damage to the heart such as ischemic injury and stress caused by pressure overload, diminishes cardiac function due to their limited ...
Laurel A. Grisanti
doaj +1 more source
Genistein Sensitizes Human Cholangiocarcinoma Cell Lines to Be Susceptible to Natural Killer Cells
Biology, 2022 Cholangiocarcinoma (CCA) is a lethal bile duct cancer, which has poor treatment outcomes due to its high resistance to chemotherapy and cancer recurrence.
Chutipa Chiawpanit +4 more
doaj +1 more source
Frontiers in Immunology, 2022 NK cells are key mediators of immune cell-mediated cytotoxicity toward infected and transformed cells, being one of the main executors of cell death in the immune system.
Ariel Ramírez-Labrada +24 more
doaj +1 more source
Volatile oil of Teucrium alopecurus sensitizes colon cancer cells to TRAIL-induced cell death
Frontiers in Bioscience-Scholar, 2021 TNF-related apoptosis-inducing ligand (TRAIL/Apo2L), a member of cytokine family, is known to selectively induce apoptosis in cancer cells. However, developing resistance to TRAIL is a major obstacle in cancer therapy.
Fatma Guesmi +7 more
doaj +1 more source
eLife, 2021 Colorectal cancer (CRC) remains a leading cause of cancer death, and its mortality is associated with metastasis and chemoresistance. We demonstrate that oxaliplatin-resistant CRC cells are sensitized to TRAIL-mediated apoptosis.
Joshua D Greenlee +6 more
doaj +1 more source
TRAF2 Controls Death Receptor-Induced Caspase-8 Processing and Facilitates Proinflammatory Signaling
Frontiers in Immunology, 2019 Tumor necrosis factor (TNF) receptor associated factor-2 (TRAF2) knockout (KO) cells were generated to investigate the role of TRAF2 in signaling by TNFR1 and the CD95-type death receptors (DRs) TRAILR1/2 and CD95.
Jennifer Kreckel +4 more
doaj +1 more source
Frontiers in Pharmacology, 2022 GABAB receptors control neuronal excitability via slow and prolonged inhibition in the central nervous system. One important function of GABAB receptors under physiological condition is to prevent neurons from shifting into an overexcitation state which ...
Musadiq A. Bhat +6 more
doaj +1 more source
Frontiers in Immunology, 2021 Both plants and animals are endowed with sophisticated innate immune systems to combat microbial attack. In these multicellular eukaryotes, innate immunity implies the presence of cell surface receptors and intracellular receptors able to detect danger ...
Thibault Roudaire +7 more
doaj +1 more source
Neoplasia: An International Journal for Oncology Research, 2005 In this study, we have evaluated the cytotoxic effect of combining two HDAC inhibitors, SAHA and TSA, with TRAIL in human multiple myeloma cell lines.
Tamer E. Fandy +4 more
doaj +1 more source