Results 1 to 10 of about 286,380 (165)
NMR structure of the death domain of the p75 neurotrophin receptor [PDF]
EMBO Journal, 1997 The intracellular domain of the p75 neurotrophin receptor (p75ICD) lacks catalytic activity but contains a motif similar to death domains found in the cytoplasmic regions of members of the tumor necrosis factor receptor family and their downstream targets.
Edvards Liepinsh +2 more
exaly +3 more sources
NOD-like receptor repertoire in the chromosome-level genome of the demosponge Dysidea avara (Schmidt, 1862) [PDF]
Frontiers in ImmunologyPorifera, one of the earliest diverging metazoans, have shown a surprisingly complex immune repertoire. However, most information to date is based on de novo transcriptome assemblies, limiting our knowledge regarding the presence and evolution of ...
Vasiliki Koutsouveli +10 more
doaj +2 more sources
Role of Glycans on Key Cell Surface Receptors That Regulate Cell Proliferation and Cell Death
Cells, 2021 Cells undergo proliferation and apoptosis, migration and differentiation via a number of cell surface receptors, most of which are heavily glycosylated.
Yin Gao +3 more
doaj +1 more source
Frontiers in Immunology, 2021 Both plants and animals are endowed with sophisticated innate immune systems to combat microbial attack. In these multicellular eukaryotes, innate immunity implies the presence of cell surface receptors and intracellular receptors able to detect danger ...
Thibault Roudaire +7 more
doaj +1 more source
Regulation of anoikis by extrinsic death receptor pathways
Cell Communication and Signaling, 2023 Metastatic cancer cells can develop anoikis resistance in the absence of substrate attachment and survive to fight tumors. Anoikis is mediated by endogenous mitochondria-dependent and exogenous death receptor pathways, and studies have shown that caspase-
Ying-Hao Han +5 more
doaj +1 more source
Identification of the Calmodulin-Binding Domains of Fas Death Receptor [PDF]
PLOS ONE, 2016 The extrinsic apoptotic pathway is initiated by binding of a Fas ligand to the ectodomain of the surface death receptor Fas protein. Subsequently, the intracellular death domain of Fas (FasDD) and that of the Fas-associated protein (FADD) interact to form the core of the death-inducing signaling complex (DISC), a crucial step for activation of caspases
Bliss J Chang +6 more
openaire +6 more sources
Structure-function analysis of barley NLR immune receptor MLA10 reveals its cell compartment specific activity in cell death and disease resistance. [PDF]
PLoS Pathogens, 2012 Plant intracellular immune receptors comprise a large number of multi-domain proteins resembling animal NOD-like receptors (NLRs). Plant NLRs typically recognize isolate-specific pathogen-derived effectors, encoded by avirulence (AVR) genes, and trigger ...
Shiwei Bai +11 more
doaj +1 more source
A novel motif identified in dependence receptors. [PDF]
PLoS ONE, 2007 Programmed cell death signaling is a critical feature of development, cellular turnover, oncogenesis, and neurodegeneration, among other processes.
Gabriel del Rio +3 more
doaj +1 more source
Identification of a ligand for the death-domain-containing receptor Apo3 [PDF]
Current Biology, 1998 The tumor necrosis factor (TNF) cytokine family regulates development and function of the immune system [1]. TNF is expressed primarily by activated lymphocytes and macrophages and induces gene transcription or apoptosis in target cells [2,3]. We have identified a novel relative of TNF that binds to the recently discovered, death-domain-containing ...
Marsters, Scot A. +5 more
openaire +2 more sources
Molecular Plant-Microbe Interactions, 2020 Nucleotide-binding leucine-rich repeat receptors (NLRs) are the most abundant type of immune receptors in plants and can trigger a rapid cell-death (hypersensitive) response upon sensing pathogens. We previously cloned the wheat NLR Sr35, which encodes a
Stephen Bolus +3 more
doaj +1 more source