Results 11 to 20 of about 288,899 (312)

Evidence for a function of death-receptor-related, death-domain-containing proteins in anoikis [PDF]

Current Biology, 1999
Normal epithelial cells undergo apoptosis if integrinmediated matrix contacts are lost, in a process termed 'anoikis'. Anoikis prevents shed epithelial cells from colonizing elsewhere, and is thus essential for maintaining appropriate tissue organisation. Aberrant oncogenes or tumor suppressor genes can cause resistance to anoikis, thereby contributing
Frisch, Steven M
openaire   +3 more sources

Enzymatic Functions for Toll/Interleukin-1 Receptor Domain Proteins in the Plant Immune System

Frontiers in Genetics, 2020
Rationally engineered improvements to crop plants will be needed to keep pace with increasing demands placed on agricultural systems by population growth and climate change.
Adam M. Bayless, Marc T. Nishimura
doaj   +1 more source

Role of ADGRG1/GPR56 in Tumor Progression

Cells, 2021
Cellular communication plays a critical role in diverse aspects of tumorigenesis including tumor cell growth/death, adhesion/detachment, migration/invasion, angiogenesis, and metastasis.
Kwai-Fong Ng, Tse-Ching Chen, Martin Stacey, Hsi-Hsien Lin   +3 more
doaj   +1 more source

A novel receptor for Apo2L/TRAIL contains a truncated death domain [PDF]

Current Biology, 1997
Apo2 ligand (Apo2L [1], also called TRAIL for tumor necrosis factor (TNF)-related apoptosis-inducing ligand [2]) belongs to the TNF family and activates apoptosis in tumor cells. Three closely related receptors bind Apo2L: DR4 and DR5, which contain cytoplasmic death domains and signal apoptosis, and DcR1, a decoy receptor that lacks a cytoplasmic tail
Marsters, S.A., Sheridan, J.P., Pitti, R.M., Huang, A., Skubatch, M., Baldwin, D., Yuan, J., Gurney, A., Goddard, A.D., Godowski, P., Ashkenazi, A.   +10 more
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Arg-GlcNAcylation on TRADD by NleB and SseK1 Is Crucial for Bacterial Pathogenesis

Frontiers in Cell and Developmental Biology, 2020
Death receptor signaling is critical for cell death, inflammation, and immune homeostasis. Hijacking death receptors and their corresponding adaptors through type III secretion system (T3SS) effectors has been evolved to be a bacterial evasion strategy ...
Juan Xue, Juan Xue, Juan Xue, Shufan Hu, Shufan Hu, Yuxuan Huang, Yuxuan Huang, Qi Zhang, Qi Zhang, Xueying Yi, Xueying Yi, Xing Pan, Xing Pan, Xing Pan, Shan Li, Shan Li, Shan Li   +16 more
doaj   +1 more source

Endogenous TRAIL-R4 critically impacts apoptotic and non-apoptotic TRAIL-induced signaling in cancer cells

Frontiers in Cell and Developmental Biology, 2022
Binding of TRAIL to its death domain-containing receptors TRAIL-R1 and TRAIL-R2 can induce cell death and/or pro-inflammatory signaling. The importance of TRAIL and TRAIL-R1/R2 in tumor immune surveillance and cancer biology has meanwhile been well ...
Anna-Christina Rambow, Anna-Christina Rambow, Insa Aschenbach, Sofie Hagelund, Doaa Tawfik, Jan-Paul Gundlach, Jan-Paul Gundlach, Sebastian Weiße, Nicolai Maass, Anna Trauzold, Anna Trauzold   +10 more
doaj   +1 more source

Chopper, a New Death Domain of the p75 Neurotrophin Receptor That Mediates Rapid Neuronal Cell Death [PDF]

Journal of Biological Chemistry, 2000
The cytoplasmic juxtamembrane region of the p75 neurotrophin receptor (p75(NTR)) has been found to be necessary and sufficient to initiate neural cell death. The region was named "Chopper" to distinguish it from CD95-like death domains. A 29-amino acid peptide corresponding to the Chopper region induced caspase- and calpain-mediated death in a variety ...
Coulson, E. J., Reid, K., Baca, M., Shipham, K. A., Hulett, S. M., Kilpatrick, T. J., Bartlett, P. F.   +6 more
openaire   +5 more sources

Inhibition of Wnt/β-catenin signaling by a soluble collagen-derived frizzled domain interacting with Wnt3a and the receptors frizzled 1 and 8. [PDF]

PLoS ONE, 2012
The Wnt/β-catenin pathway controls cell proliferation, death and differentiation. Several families of extracellular proteins can antagonize Wnt/β-catenin signaling, including the decoy receptors known as secreted frizzled related proteins (SFRPs), which ...
Ismaïl Hendaoui, Elise Lavergne, Heun-Sik Lee, Seong Hyun Hong, Hak-Zoo Kim, Christelle Parent, Nathalie Heuzé-Vourc'h, Bruno Clément, Orlando Musso   +8 more
doaj   +1 more source

PD-L1 is expressed on human activated naive effector CD4+ T cells. Regulation by dendritic cells and regulatory CD4+ T cells.

PLoS ONE, 2021
The T cell expression of various co-signalling receptors from the CD28 immunoglobulin superfamily (Inducible T cell co-stimulator (ICOS), Programmed cell death 1(PD-1), cytotoxic T lymphocyte associated protein 4 (CTLA-4), B and T lymphocyte attenuator ...
Fabienne Mazerolles, Frédéric Rieux-Laucat   +1 more
doaj   +2 more sources

Structure of TRAF Family: Current Understanding of Receptor Recognition

Frontiers in Immunology, 2018
Tumor necrosis factor receptor–associated factor (TRAF) proteins are key signaling molecules that function in various cellular signaling events including immune response, cell death and survival, development, and thrombosis.
Hyun H. Park
doaj   +1 more source