Results 51 to 60 of about 589,147 (148)
Role of p63 and p73 isoforms on the cell death in patients with hepatocellular carcinoma submitted to orthotopic liver transplantation. [PDF]
PLoS ONE, 2017 Patients with hepatocellular carcinoma (HCC) submitted to orthotopic liver transplantation (OLT) have a variable 5-year survival rate limited mostly by tumor recurrence.
Raúl González +13 more
doaj +1 more source
Apoptotic Receptors and CD107a Expression by NK Cells in an Interaction Model with Trophoblast Cells
Current Issues in Molecular BiologyNatural killer cells (NK cells) exert cytotoxicity towards target cells in several ways, including the expression of apoptosis-mediating ligands (TRAIL, FasL).
Valentina A. Mikhailova +6 more
doaj +1 more source
Frontiers in Cellular Neuroscience, 2019 Neurotrophins (NTs) are a subset of the neurotrophic factor family. These growth factors were originally named based on the nerve growth functional assays used to identify them. NTs act as paracrine or autocrine factors for cells expressing NT receptors.
Horacio Uri Saragovi +7 more
doaj +1 more source
The Janus face of death receptor signalling during tumour immunoediting.
Frontiers in Immunology, 2016 Cancer immune-surveillance is essential for the inhibition of carcinogenesis. Malignantly transformed cells can be recognised by both the innate and adaptive immune systems through different mechanisms.
Eimear O' Reilly +3 more
doaj +1 more source
Apoptosis signaling by death receptors
European Journal of Biochemistry, 1998 Death receptors have been recently identified as a subgroup of the TNF‐receptor superfamily with a predominant function in induction of apoptosis. The receptors are characterized by an intracellular region, called the death domain, which is required for the transmission of the cytotoxic signal.
Schulze-Osthoff, Klaus +4 more
openaire +5 more sources
Role Of S-Nitrosylation In The Extrinsic Apoptotic Signalling Pathway In Cancer
Redox Biology, 2015 One of the key features of tumour cells is the acquisition of resistance to apoptosis. Thus, determining therapeutic strategies that circumvent apoptotic resistance and result in tumor regression is a challenge.
Stéphanie Plenchette
doaj +1 more source
Piperlongumine inhibits cell growth and enhances TRAIL-induced apoptosis in prostate cancer cells
Asian Pacific Journal of Tropical Biomedicine, 2020 Objective: To investigate whether piperlongumine can sensitize prostate cancer cells to tumor necrosis factor-related apoptosis- inducing ligand (TRAIL) and trigger apoptosis in prostate cells.
Gorkem Kismali +8 more
doaj +1 more source
The ‘complexities’ of life and death: Death receptor signalling platforms
Experimental Cell Research, 2012 Cell death is critical to the normal functioning of multi-cellular organisms, playing a central role in development, immunity, inflammation, and cancer progression. Two cell death mechanisms, apoptosis and necroptosis, are dependent on the formation of distinct multi-protein complexes including the DISC, Apoptosome, Piddosome and Necrosome following ...
Dickens, Laura S. +3 more
openaire +2 more sources
Scientific ReportsGABAB receptors mediate prolonged inhibition in the brain and are important for keeping neuronal excitation and inhibition in a healthy balance. However, under excitotoxic/ischemic conditions, GABAB receptors are downregulated by dysregulated endocytic ...
Musadiq A. Bhat +4 more
doaj +1 more source
Therapeutic targeting of TRAIL death receptors. [PDF]
Biochem Soc Trans, 2023 Di Cristofano F +14 more
europepmc +1 more source