Results 91 to 100 of about 138,899 (263)
Drug Delivery, 2017 Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-based combination therapy and gene therapy are new strategies to potentially overcome the limitations of TRAIL, however, the lack of efficient and low toxic vectors remains the major ...
Shengpeng Wang +7 more
doaj +1 more source
A DR4, DR5 Targeting Conjugated TRAIL Treatment for Colorectal Carcinogenesis: A Way to Future? [PDF]
Pharmaceutical SciencesTRAIL or tumor necrosis factor-related apoptosis-inducing ligand has been one of the major frontiers for the chemotherapeutic approach to treating carcinogenesis.
Parikshit Roychowdhury +7 more
doaj +1 more source
, 1967 Print on cardstock of buildings and cars in black ink. Signed "D. Trail 67", titled "Backlot" and numbered 7/15. Caption on the verso reads "Rear view of Pandora's Box Gallery, Victoria BC 1967, by David (?) Trail, one of many young artists who visited ...
Trail, D.
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The NO TRAIL to YES TRAIL in cancer therapy (Review)
International Journal of Oncology, 2007 Treatment of cancer patients with conventional therapies (chemotherapy, hormonal therapy, immunotherapy and radiation) respond initially well and experience prolonged tumor-free survival. However, in many patients tumor recurrences and relapses occur and such tumors exhibit the resistant phenotype i.e.
Ji Yeun, Lee +5 more
openaire +3 more sources
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Combining an improvement to PARMA trailing with trailing analysis
Proceedings of the 4th ACM SIGPLAN international conference on Principles and practice of declarative programming, 2002 Trailing of bindings in the PARMA variable representation is expensive in time and space. Two schemes are presented that lower its cost: the first is a technique that halves the space cost of trailing in PARMA. It can be used with conditional and unconditional trailing.
Schrijvers, Tom, Demoen, Bart
openaire +4 more sources
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Appalachian Trail in North Carolina
, 2014 In 1930, the Carolina Appalachian Trail Club was organized for the purpose of completing the western North Carolina segment of the Appalachian Trail. Its home was in Asheville.
Carolina Appalachian Trail Club;
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Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Research on issues in the protection of clinical trial human subjects in China: a Delphi study
BMC Medical EthicsBackground This study aims to identify current deficiencies in the protection of human subjects participating in clinical trials in China and propose strategies for safeguarding their rights.
Xiuqiao Yang +9 more
doaj +1 more source