Results 61 to 70 of about 447,838 (312)

Dalgleish scores difference amongst professional roles within the greater child welfare community

open access: yesChild Protection and Practice
Background: The central tension of the child welfare system is the need to protect children while also encouraging the stability of families. Researchers have attempted to capture this conflict through the use of the Dalgleish Scale (Fluke et al., 2016),
Matthew Trail
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

open access: yesFEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt   +8 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

The information trail

open access: yeseLife, 2016
The ability of a wild baboon to acquire and exploit social information depends on its individual characteristics and its position within various social networks.
openaire   +3 more sources

Old Oregon Trail from the Missouri to the Pacific

open access: yes, 1943
Relief shown pictoriallyShows the Old Oregon Trail, Mormon Trail, Lewis and Clark's route, Applegate Trail, Naches Pass Trail, Barlow Road, and Fremont's routeIncludes pictorial representations of landmarks, animals, and peopleThis archived document is ...

core  

Targeting of keloid with TRAIL and TRAIL-R2/DR5

open access: yesJournal of Dermatological Treatment, 2020
Keloid is a common and frequently-occurring disease in plastic surgery, and its ugly appearance and itching symptoms bring mental and life pain to patients. However, the clinical treatment of keloid, such as drug injection treatment, surgical resection, cryotherapy, laser treatment and other therapeutic effects are poor.
Pengfei, Sun   +3 more
openaire   +2 more sources

Appalachian Trail 1981

open access: yes, 1981
"March 1981."; Cover title of accompanying text: Comprehensive plan.; Spine title of accompanying text: Appalachian Trail comprehensive plan.; "Source Data: Map base is Geological Survey 1:2,500,000 scale map, dated 1972."; Accompanied by text ...

core  

Pedological aspects as environmental quality indicators of a touristic trail in the Serra do Cipó National Park/MG

open access: yesREM: International Engineering Journal
Soil provides important support for anthropogenic activities, and earthen trails, which have always been present in the natural landscape, are routes of access to various tourist attractions. In recent decades, trails have been widely used as a method of
Ricardo Eustáquio Fonseca Filho   +3 more
doaj   +1 more source

La promoción del turismo rural a través del "trail running": el caso de Carrícola en la comarca de "La Vall d'Albaida"

open access: yesPASOS Revista de Turismo y Patrimonio Cultural, 2017
El running se ha convertido en poco tiempo en un deporte de masas, generando todo un negocio a su alrededor y un impacto económico importante en aquellas localidades que albergan este tipo de eventos.
FEDERICO SOLER VAYÁ   +1 more
doaj   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

open access: yesFEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux   +7 more
wiley   +1 more source

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