Results 91 to 100 of about 459,788 (312)

Janis Trail

, 1980
Photograph of Janice Trail at his home near Claytor Lake in Pulaski County ...
Trail, Janice;
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Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Alterações na vegetação herbácea de floresta ombrófila densa decorrentes do uso em uma trilha turística na Serra do Mar em São Paulo, Brasil Alterations in the herbaceous vegetation along a tourist trail in the Serra do Mar, São Paulo, Brazil

Acta Botânica Brasílica, 2011
O estudo analisou a vegetação herbácea ao longo de uma trilha de uso público intensivo nos parques Natural Municipal Nascentes de Paranapiacaba (PNMNP) e Estadual da Serra do Mar (PESM).
Luísa Almeida Maciel, Maria Francisca Roncero Siles, Marisa Dantas Bitencourt   +2 more
doaj   +1 more source

Buckeye Trail Becomes Ohio's Official Hiking Trail

, 1967
Governor James Rhodes signing a bill to make the Buckeye Trail the official hiking trail of Ohio, April 27, 1967. Pictured with Governor Rhodes (from left to right) are Kenneth D.

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SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

La montagne dans le sang

Bulletin de la Dialyse à Domicile, 2019
En France, près de 3 millions de personnes sont touchées par les maladies du rein. L’insuffisance rénale chronique touche environ 80 000 personnes. Sur ces 80 000 per¬sonnes touchées, 44 % d’entre elles bénéficient d’une greffe de rein, et 56 % sont ...
Fabrice Huré
doaj   +1 more source

Recreational Demand for Equestrian Trail-Riding [PDF]

Using data collected from a combination of on-site and on-line surveys, this study examines recreational demand for equestrian trail-riding in Kentucky.
Blackwell, Melanie, Pagoulatos, Angelos, Hu, Wuyang, Auchter, Katharine   +3 more
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Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

The NO TRAIL to YES TRAIL in cancer therapy (Review)

International Journal of Oncology, 2007
Treatment of cancer patients with conventional therapies (chemotherapy, hormonal therapy, immunotherapy and radiation) respond initially well and experience prolonged tumor-free survival. However, in many patients tumor recurrences and relapses occur and such tumors exhibit the resistant phenotype i.e.
Ji Yeun, Lee, Sara, Huerta-Yepez, Mario, Vega, Stavroula, Baritaki, Demetrios A, Spandidos, Benjamin, Bonavida   +5 more
openaire   +3 more sources

Hikers on the Buckeye Trail

, 1963
Photograph of a busload of Buckeye Trail hikers, 1963. The Buckeye Trail winds for about 1,444 miles through Ohio from Lake Erie near Cleveland to the Ohio River near Cincinnati. The Buckeye Trail Association, a non-profit organization created in June of

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