Results 161 to 170 of about 479,268 (266)

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

Navigating Adversity: Non-Completion and Evacuation of Trail Runners at the 2022 Magoebaskloof Forest Marathon. [PDF]

S Afr J Sports Med
Maleka TE, Van Rensburg AJ, Viljoen C, Ramkilawon G, Ramagole DA, Nair A, van Rensburg DJ.   +6 more
europepmc   +1 more source

Clinical Outcomes of SEEG‐Guided Radiofrequency Thermocoagulation in Children With Focal Drug‐Resistant Epilepsy: A Multicenter Real‐World Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Stereoelectroencephalography‐guided radiofrequency thermocoagulation (SEEG‐RFTC) has emerged as a safe and effective minimally invasive treatment for children with drug‐resistant focal epilepsy. Although evidence from real‐world studies remains limited, numerous pediatric cases have demonstrated promising outcomes. This retrospective
Weitao Chen, Stéphane Jean, Weihong Liu, Yihai Dai, Xinrong Fang, Xiaoqiang Wei, Shan Chen, Shiwei Song   +7 more
wiley   +1 more source

Genetically engineered human cell-based microrobots for selective cancer cell death. [PDF]

Sci Adv
Dogan NO, Suadiye E, Unangst J, Dayan CB, Richter G, Cingöz A, Bagci-Onder T, Sitti M.   +7 more
europepmc   +1 more source

The Role of Calcitonin Gene‐Related Peptide in High‐Altitude Headache: A Prospective Field Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective High‐altitude headache (HAH) is a common neurological condition associated with rapid ascent to high altitude. The pathophysiological mechanisms underlying HAH remain incompletely understood. Calcitonin gene‐related peptide (CGRP), a neuropeptide implicated in migraine pathophysiology, may play a key role in the pathophysiology of ...
Roman Schniepp, Ludwig Karrasch, Helena Breitenstein, Andreas Straube, Katharina Kamm   +4 more
wiley   +1 more source

Focused Ultrasound-Triggered Burst Release and Enrichment of Engineered Bacteria for Tumor Therapy. [PDF]

Biomater Res
Yoo J, Hwang Y, Park M, Ha H, Choi MR, Lim SI, Park B, Ahn YJ, Kim WJ, Jung GY, Kim HH.   +10 more
europepmc   +1 more source

TNF-Related Apoptosis-Inducing Ligand (TRAIL)–Armed Exosomes Deliver Proapoptotic Signals to Tumor Site

Clinical Cancer Research, 2016
L. Rivoltini, C. Chiodoni, P. Squarcina, M. Tortoreto, A. Villa, B. Vergani, M. Bürdek, Laura Botti, Ivano Arioli, A. Cova, G. Mauri, E. Vergani, Beatrice Bianchi, P. Della Mina, L. Cantone, V. Bollati, N. Zaffaroni, A. Gianni, M. Colombo, V. Huber   +19 more
semanticscholar   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

βIII-tubulin can act as a brake on extrinsic apoptosis in pancreatic cancer. [PDF]

Cell Death Dis
Sharbeen G, Kokkinos J, Schulstad G, Pandzic E, Youkhana J, Ma Z, Ignacio RMC, Raina AS, Chiang S, Boyer C, Haghighi KS, Gunawarman M, Goldstein D, Gebski V, Pajic M, Davis ME, Arkell OSM, Kopecky C, Gonzales-Aloy E, Ishak A, Erkan M, Morton JP, Kavallaris M, Gunning PW, Hardeman EC, Johns A, Gill AJ, Whan RM, Mawson A, Pitiyarachchi O, Australian Pancreatic Cancer Genome Initiative, McCarroll JA, Phillips PA.   +32 more
europepmc   +1 more source

Choroid Plexus Enlargement and USPIO‐Based Inflammatory Feature in Cerebral Small Vessel Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The choroid plexus (CP) is a key component of the blood–cerebrospinal fluid barrier (BCSFB), but its mechanism of action in cerebral small vessel disease (CSVD) remains unclear. This study investigated CP volume (CPV) alterations and their association with conventional imaging markers in CSVD and explored the underlying role of ...
Yongqiang Qu, Xiaoning Ren, Cuihua Fan, Chun Li, Lijie Zhang, Zaiqiang Zhang, Shaowu Li, Zhongmeng Lai, Bin Cai, Ying Fu, Yi Lin, Zhibao Zhu   +11 more
wiley   +1 more source