Results 81 to 90 of about 479,268 (266)

Overcoming resistance to TRAIL-induced apoptosis in solid tumor cells by simultaneously targeting death receptors, c-FLIP and IAPs

International Journal of Oncology, 2016
The discovery of the TRAIL protein and its death receptors DR4/5 changed the horizon of cancer research because TRAIL specifically kills cancer cells. However, the validity of TRAIL-based cancer therapies has yet to be established, as most cancer cells ...
Ying Huang, Xiang Yang, Tianrui Xu, Q. Kong, Yaping Zhang, Yuehai Shen, Yunlin Wei, Guan-lin Wang, Kwen-Jen Chang   +8 more
semanticscholar   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Water Erosion Processes on the Geotouristic Trails of Serra da Bocaina National Park Coast, Rio de Janeiro State, Brazil

Soil Systems
Conservation units are strategic territories that have a high demand for public use, as they protect attractions of great scenic beauty, geodiversity sites, and numerous leisure areas.
Guilherme Marques de Lima, Antonio Jose Teixeira Guerra, Luana de Almeida Rangel, Colin A. Booth, Michael Augustine Fullen   +4 more
doaj   +1 more source

Functional TRAIL receptors in monocytes and tumor-associated macrophages: A possible targeting pathway in the tumor microenvironment

OncoTarget, 2016
Despite the accepted dogma that TRAIL kills only tumor cells and spares normal ones, we show in this study that mononuclear phagocytes are susceptible to recombinant TRAIL via caspase-dependent apoptosis.
Manuela Liguori, C. Buracchi, F. Pasqualini, Francesca Bergomas, Samantha Pesce, M. Sironi, F. Grizzi, A. Mantovani, Cristina Belgiovine, P. Allavena   +9 more
semanticscholar   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

TRAIL receptor gene editing unveils TRAIL-R1 as a master player of apoptosis induced by TRAIL and ER stress

OncoTarget, 2016
TRAIL induces selective tumor cell death through TRAIL-R1 and TRAIL-R2. Despite the fact that these receptors share high structural homologies, induction of apoptosis upon ER stress, cell autonomous motility and invasion have solely been described to ...
F. Dufour, T. Rattier, A. Constantinescu, L. Zischler, Aymeric Morlé, Hazem Ben Mabrouk, Étienne Humblin, G. Jacquemin, E. Szegezdi, F. Delacôte, N. Marrakchi, G. Guichard, C. Pellat-Deceunynck, P. Vacher, Patrick Legembre, C. Garrido, O. Micheau   +16 more
semanticscholar   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Alterações na vegetação herbácea de floresta ombrófila densa decorrentes do uso em uma trilha turística na Serra do Mar em São Paulo, Brasil Alterations in the herbaceous vegetation along a tourist trail in the Serra do Mar, São Paulo, Brazil

Acta Botânica Brasílica, 2011
O estudo analisou a vegetação herbácea ao longo de uma trilha de uso público intensivo nos parques Natural Municipal Nascentes de Paranapiacaba (PNMNP) e Estadual da Serra do Mar (PESM).
Luísa Almeida Maciel, Maria Francisca Roncero Siles, Marisa Dantas Bitencourt   +2 more
doaj   +1 more source

Getting TRAIL back on track for cancer therapy

Cell Death and Differentiation, 2014
Unlike other members of the TNF superfamily, the TNF-related apoptosis-inducing ligand (TRAIL, also known as Apo2L) possesses the unique capacity to induce apoptosis selectively in cancer cells in vitro and in vivo.
Johannes Lemke, Johannes Lemke, S. Karstedt, J. Zinngrebe, H. Walczak   +4 more
semanticscholar   +1 more source