Results 61 to 70 of about 479,268 (266)

Improvement of Pharmacokinetic Profile of TRAIL via Trimer-Tag Enhances its Antitumor Activity in vivo

Scientific Reports, 2017
TNF-related apoptosis-inducing ligand (TRAIL/Apo2L) has long been considered a tantalizing target for cancer therapy because it mediates activation of the extrinsic apoptosis pathway in a tumor-specific manner by binding to and trimerizing its functional
Haipeng Liu, Danmei Su, Jinlong Zhang, Shuai-Shuai Ge, Youwei Li, Fei Wang, M. Gravel, A. Roulston, Qin Song, W. Xu, Joshua G. Liang, G. Shore, Xiaodong Wang, P. Liang   +13 more
semanticscholar   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Osteoprotegerin Is a Receptor for the Cytotoxic Ligand TRAIL*

Journal of Biological Chemistry, 1998
TRAIL is a tumor necrosis factor-related ligand that induces apoptosis upon binding to its death domain-containing receptors, DR4 and DR5. Two additional TRAIL receptors, TRID/DcR1 and DcR2, lack functional death domains and function as decoy receptors ...
J. Emery, P. Mcdonnell, M. Burke, K. Deen, S. Lyn, C. Silverman, E. Dul, E. Appelbaum, C. Eichman, R. DiPrinzio, R. Dodds, I. James, Martin Rosenberg, John C. Lee, P. Young   +14 more
semanticscholar   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Dynamics of the left ventricular ejection fraction after revascularization in patients with heart failure with preserved ejection fraction, association with the TRAIL protein [PDF]

Терапевтический архив
Aim. To study the association of dynamics of the ejection fraction (EF) of the left ventricle (LV) with the development of adverse cardiovascular events within 12 months after revascularization in patients with chronic heart failure with preserved LV EF (
Elena A. Kuzheleva, Alla A. Garganeeva, Olga V. Tukish, Karina N. Vitt, Mikhail Iu. Kondratiev, Mikhail V. Soldatenko   +5 more
doaj   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Permafrost characterization, mapping, modelling, and knowledge sharing in support of construction of community roads and trails over sensitive tundra. Kugluktuk, Nunavut, Canada

Arctic Science
As part of an Inuit-led initiative, a collaborative research project combined scientific methods and Inuit knowledge to design an environmentally friendly and climate change-resilient access route from the community of Kugluktuk to Kugluk Territorial ...
Michel Allard, Stephanie Coulombe, Marc-André Ducharme, Samuel Bilodeau, Larry Adjun, Leesee Papatsie, Gerry Attatahak, Samuel Gagnon   +7 more
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Differential white blood cell count and epigenetic clocks: a bidirectional Mendelian randomization study

Clinical Epigenetics
Background Human aging and white blood cell (WBC) count are complex traits influenced by multiple genetic factors. Predictors of chronological age have been developed using epigenetic clocks.
Manli Sun, Huan Yang, Yang Hu, Jiaqi Fan, Mingjing Duan, Jingqi Ruan, Shichang Li, Yang Xu, Yue Han   +8 more
doaj   +1 more source

Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis

Nature, 2009
In microorganisms, noise in gene expression gives rise to cell-to-cell variability in protein concentrations. In mammalian cells, protein levels also vary and individual cells differ widely in their responsiveness to uniform physiological stimuli. In the
Sabrina L. Spencer, S. Gaudet, J. Albeck, J. Burke, P. Sorger   +4 more
semanticscholar   +1 more source